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https://www.selleckchem.com/products/dnqx.html Our results question PAS effectiveness under these conditions.Significance Statement Paired Associative Stimulation (PAS) can be applied non-invasively to modulate corticomotor plasticity in humans. However, our understanding of how we can use paired stimuli to produce the greatest beneficial reshaping of corticomotor connections in vivo is still rudimentary. We completed a systematic study varying inter-stimulus intervals between cortical and muscle stimulation in a freely-behaving rat PAS model, following the principles of spike-timing dependent plasticity (STDP). Crucially, our experiments have not demonstrated that the STDP model is effective in vivo using our PAS protocol. We discuss several other factors in addition to the inter-stimulus interval which may play a larger role in driving plasticity, and potential ways that the field can approach future work. Copyright © 2020 Ting et al.AIM To train and individually validate the neuropathologists in digital primary diagnosis and frozen section reporting using a novel protocol endorsed by the Royal College of Pathologists. The protocol allows early exposure to live digital reporting in a risk mitigated environment. METHODS Two specialist neuropathologists completed training in the use of a digital microscopy system for primary neuropathological diagnosis and frozen section assessment. Participants were exposed to training sets of 20 histology cases and 10 frozen sections designed to help them identify their personal digital diagnostic pitfalls. Following this, the pathologists viewed 340 live, complete neuropathology cases. All primary diagnoses were made on digital slides with immediate glass slide reconciliation before final case sign-out. RESULTS There was 100% clinical concordance between the digital slide and glass slide assessment of frozen section cases for each pathologist, and these assessments corresponded with the ground truth diagnoses obtained from examin

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