https://www.selleckchem.com/products/Romidepsin-FK228.html Worldwide, 10-20% of women experience depression during pregnancy. In sub-Saharan countries, depression during pregnancy is estimated to be 15-57%. Even though there is a high burden of depression during pregnancy, little attention has been given to identify sociodemographic and obstetric determinants in diverse populations like Ethiopia. To identify sociodemographic and obstetric determinants of antenatal depression among women attending an antenatal clinic at Jimma Medical Center, southwest Ethiopia. A case-control study was conducted among 246 pregnant mothers (82 cases and 164 controls) attending an antenatal clinic in Jimma Medical Center from June 1 to August 30, 2019. Antenatal depression was assessed using the Beck Depression Inventory-II. Epidata 3.1 and SPSS v24 were used for data entry and analysis, respectively. Adjusted odds ratios (AOR) and 95%CIs were estimated using logistic regression models. Statistical significance was set at <0.05. Married mothers were 67% (AOR=0.33, 95%CI 0.1having wanted pregnancy and occupation status (housewives, private workers and government employees) can protect mothers from developing antenatal depression. Mothers with third trimester pregnancy were four times more likely to have depression. Designing a screening and intervention strategy for antenatal depression must consider the aforementioned protective and risk factors. Birth spacing is key in ensuring the health of mothers and their children as well as determining population growth. Most of the mothers in developing nations including Ethiopia have been practicing short inter-birth intervals. There is a paucity of studies concerned with suboptimal birth spacing among women in reproductive age in the study area. This study aims to identify the determinants of sub-optimal birth spacing among reproductive-age women in Gedeo zone, South Ethiopia. A community-based unmatched case-control study was undertaken among