https://www.selleckchem.com/products/epalrestat.html RESULTS When correcting axial myopia using spectacles, the eye's 2nd nodal point shifts towards the retina and away from the scattering plane, leading to an increase in straylight. Meanwhile, straylight should theoretically decrease in hyperopic eyes. Contact lenses keep the 2nd nodal point relative stable, leading to a very minor change in straylight with axial length. Our model has shown good agreement with previously taken straylight measurements in real eyes, explaining the observed change of straylight with ocular axial length. CONCLUSION We proposed an explanation for the underlying optical mechanism for the clinically observed increase of straylight with axial myopia, when corrected with glasses. Our model predicts that the increase can be as high as 0.12 log units for a myopic eye with 10 dioptres, which agrees with prior observations. © 2020 The Authors Ophthalmic & Physiological Optics © 2020 The College of Optometrists.BACKGROUND Arterial rupture mainly affects older horses. The reason why older horses are more prone to arterial rupture and which underlying vascular changes predispose older horses to aortic rupture is still unclear. OBJECTIVES To investigate the effect of ageing on the equine arterial wall and blood pressure. STUDY DESIGN Cohort study. METHODS Non-invasive blood pressure measurement using a tail cuff and vascular ultrasound from aorta, common carotid artery and external iliac artery was performed in 50 healthy young (3-7 years) and 50 healthy old Warmblood horses (>18 years). Arterial diameters and cross-sectional areas, and arterial wall thickness were measured offline. Regional arterial wall stiffness of the aorta and common carotid artery was assessed using pulse wave velocity, while lumen area/diameter change, strain, compliance and distensibility were calculated to assess local arterial wall stiffness. RESULTS No difference in blood pressure was found between old and young horses.