https://www.selleckchem.com/products/curzerene.html The online server for SemanticCS is freely available at http//qianglab.scst.suda.edu.cn/semanticCS/.Deficits in interpersonal communication along with difficulty in putting oneself into the shoes of others characterizes individuals with Autism Spectrum Disorder (ASD). Additionally, they exhibit atypical looking pattern causing them to miss aspects related to understanding other's preference for a context that is crucial for effective social communication. Prior research studies show the use of multiplayer platforms can improve interaction among these individuals. However, these multiplayer platforms do not demand players to understand each other's preference, important for effective social interaction. In this work, we have developed a multiplayer interaction platform using virtual reality augmented with eye-tracking technology. Thirty-six participants comprising of individuals with ASD (n = 18; GroupASD) and typically developing (TD) individuals (n = 18; GroupTD) interacted in pairs within each participant group using our platform. Results indicate that both GroupASD and GroupTD showed improvement in performance across the tasks with the GroupTD performing better than the GroupASD. Additionally, the eye-gaze data indicated an underlying relationship between one's looking pattern and task performance that was differentiated between the GroupASD and GroupTD. The current results indicate a potential of our multiplayer interaction platform to serve as a complementary tool in the hands of the interventionist promoting social reciprocity and interaction among individuals with ASD.Spatial presence encompasses the user's ability to experience a sense of "being there". While particular attention was given to assess spatial presence in real and virtual environments, few have been interested in measuring it in telepresence situations. To bridge this gap, the present work introduces a study that compares the execution of a ta