https://www.selleckchem.com/products/d609.html PRACTICAL APPLICATION Mulberry fruits (Morus alba L.) have been commonly consumed as juice or jam. It is a rich source of anthocyanins that might be associated with beneficial effects on human health, including the anti-oxidant, anti-inflammatory, anti-obesity, and anti-diabetic effects. Mulberry vinegar was produced by alcohol and acetic fermentation of mulberry juice, and they possessed a protective effect against LPS/IFN-γ-stimulated inflammatory responses in glial cells via regulation of glial activation and NF-κB signaling pathway (i.e., downregulation of iNOS, COX-2, TLR4, p-IκB, and NF-κB p65 protein expressions). Although further research especially animal and clinical trials are still necessary, the present study will be helpful to scale-up the production of functional vinegar with neuroprotective and anti-inflammatory properties using mulberry.Vaso-occlusive episodes (VOEs) are a major concern in patients with sickle cell disease (SCD). Exposure to systemic corticosteroids has been suspected to increase the occurrence of VOEs in case reports or series. No comparative study has been conducted to investigate this risk, which is still debated. Several clinical trials demonstrated the effectiveness of corticosteroids for the treatment of VOEs, but with increased rates of readmission. The aim of the study was to assess the risk of hospitalization for VOE associated with exposure to systemic corticosteroids in patients with SCD. We used a case-case-time-control design in a nationwide population-based cohort built in the French national health insurance database between 2010 and 2018. The population included all patients with SCD with at least 1 hospitalization for VOE. Corticosteroids were identified using out-of-hospital dispensing data. The outcome was the first hospitalization for VOE. The case-case-time-control design induces self-adjustment for time-invariant confounders, including genotype. Analyses were adjus