https://www.selleckchem.com/products/g140.html In this review, sequential stages of the development of negative disorders doctrine are presented beginning from first description of negative symptoms (Aretaeus of Cappadocia - AD I-II) and the first deficit classification (including two polar types congenital and acquired dementia by J.-E. Esquirol) to indigenous Russian (I.M. Balinsky, I.P. Merzheevsky, S.S. Korsakov, V.P. Serbsky and others) and foreign (B. Morel, H. Schüle, K. Kahlbaum, E. Hecker) studies of the middle 19th - beginning of 20th century. Special attention in this review of studies in prenosological period is given to the W. Griesinger's development of the main statements of deficit changes' classification and development pathways. Authors' studies created conditions not only for psychopathological construct of negative disorders to be set apart into particular category - «secondary insanity» (a group of psychiatric set of symptoms, which accumulate manifestations of mental deficit), but for to be subsequently clinically studied. To study the prevalence of somatic diseases in patients with mental disorders based on the results of medical examination in Moscow mental health clinics in 2018. A retrospective analysis of the results of the clinical examinations of 6492 outpatients, which accounted for 79.5% of patients who underwent medical examination in this time period. Comorbid somatic diseases were found in 4883 (75%) patients. Hypertension and non-insulin-dependent diabetes mellitus were most frequent with the prevalence higher than in the general population of the Russian Federation. Patients with diagnosed schizophrenia, along with hypertension and diabetes mellitus, have found to be at increased risk of diseases of the endocrine system and metabolic disorders. The incidence of the mentioned diseases is not higher than that reported in literature. The higher prevalence of socially relevant diseases (hypertension, diabetes mellitus) among patients