https://www.selleckchem.com/ The results evidenced that the double mutation of the PDK1 pleckstrin homology (PH) domain resulted in an enhancement of the negative valence system shown as an increase of responses of fear- and anxiety-like behaviors in anxiogenic situations. Interestingly, this seemed to be specific of YA and found regulated at middle age. In contrast, cognitive deficits, as measured in a spatial working memory task, were found in both YA and MA mutants and independently of the level of their anxious-like profiles. These distinct age- and function-dependent impacts would be in agreement with the distinct cortical and limbic deficits in the Akt signaling in the brain we have recently described in these same animals. The elicitation of age- and neuronal-dependent specific patterns suggests that fine-tuning the intensity of the PKB/Akt signal that enables diverse physiological response has also its in vivo translation into the negative valence system and age is a key regulatory factor.The purpose of the present study is to investigate the influence of music tempo on inhibition control. An electroencephalogram (EEG) was recorded when participants performed a Go/No-go task while listening to slow (54 bpm), medium-paced (104 bpm), fast (154 bpm), or no music. The behavioral results showed that the accuracies for the No-go trials were lower in the fast than in the slow tempo music conditions, while the accuracies for the Go trials were also lower in the fast tempo than in no music conditions. The event-related potential (ERP) study results showed that larger N2 and P3 amplitudes were elicited by No-go than by Go conditions. Moreover, the difference N2 (N2d) amplitudes observed by No-go vs. Go condition were larger in fast music than in medium-paced, slow, and no music conditions, indicating more consumption of cognitive resources in the process of conflict monitoring under the fast music condition. However, no such differences were observed among medium-pace