https://www.selleckchem.com/products/bgb-290.html Institution-level strategic changes may be associated with heart transplant volume and outcomes. To describe changes in practice that markedly increased heart transplant volume at a single center, as well as associated patient characteristics and outcomes. A pre-post cohort study was conducted of 107 patients who underwent heart transplant between September 1, 2014, and August 31, 2019, at Yale New Haven Hospital before (September 1, 2014, to August 31, 2018; prechange era) and after (September 1, 2018, to August 31, 2019; postchange era) a strategic change in patient selection by the heart transplant program. Strategic change in donor and recipient selection at Yale New Haven Hospital that occurred in August 2018. Outcome measures were transplant case volume, donor and recipient characteristics, and 180-day survival. A total of 49 patients (12.3 per year; 20 women [40.8%]; median age, 57 years [interquartile range IQR, 50-63 years]) received heart transplants in the 4 years of the prechange eraallocation of currently unused donor hearts. With population aging, the burden of many age-related chronic conditions, including kidney failure, is increasing globally. To investigate the risks of kidney failure and death in adults with incident stage IV chronic kidney disease (CKD). This population-based cohort study obtained data recorded between July 30, 2002, and March 31, 2014, from the linked laboratory and administrative data set of Alberta Health in Alberta, Canada. All adults of the province of Alberta with stage IV CKD (estimated glomerular filtration rate [eGFR] of 15-30 mL/min/1.73 m2) were eligible for inclusion. Included individuals were followed up from study entry until the date of kidney failure, death, or censoring, whichever occurred first. Observations were censored at the date of emigration from the province, the study end date (March 31, 2017), or at 10 years after study entry. Data analyses were performe