https://www.selleckchem.com/products/ml349.html It has no effect on children with gastroenteritis who do not present with dehydration in developing countries. While ondansetron is effective in controlling vomiting and reducing the rate of hospitalization, there is no evidence that it is effective in reducing the rate of readmission.What is Known• In high-income countries, ondansetron can reduce the use of intravenous fluids in children with gastroenteritis and dehydration.• No systematic review and meta-analysis of randomized controlled trials were done in a developing country setting.What is New• In developing countries, ondansetron reduces the use of intravenous fluids in children with gastroenteritis and dehydration.• It has no effect on children with gastroenteritis but without dehydration.Barrett's oesophagus is the only known precursor to oesophageal adenocarcinoma (OAC). Although guidelines on the screening and surveillance exist in Barrett's oesophagus, the current strategies are inadequate. Oesophagogastroduodenoscopy (OGD) is the gold standard method in screening for Barrett's oesophagus. This invasive method is expensive with associated risks negating its use as a current screening tool for Barrett's oesophagus. This review explores current definitions, epidemiology, biomarkers, surveillance, and screening in Barrett's oesophagus. Imaging modalities applicable to this condition are discussed, in addition to future developments. There is an urgent need for an alternative non-invasive method of screening and/or surveillance which could be highly beneficial towards reducing waiting times, alleviating patient fears and reducing future costs in current healthcare services. Vibrational spectroscopy has been shown to be promising in categorising Barrett's oesophagus through to high-grade dysplasia (HGD) and OAC. These techniques need further validation through multicentre trials.Patients with Helicobacter pylori-naive mucosa may develop a pale, depressed signet