This study investigated the relationship between professionalism factors and undergraduate occupational therapy students' fieldwork performance as measured by the Student Practice Education Form-Revised Edition (SPEF-R). 135 undergraduate occupational therapy students (86% 20-24 years old; 87% female) completed the Penn State College of Medicine Professionalism Questionnaire (PSCOPQ). Student fieldwork performance was measured using the Student Practice Evaluation Form-Revised Edition (SPEF-R). Multi-linear regression with bootstrapping was completed on the midway and final SPEF-R scores. Regression analysis demonstrated a range of professionalism variables to be significant predictors of fieldwork performance at the midway assessment of their fieldwork placement Equity was a significant predictor of Self-management Skills; Enrichment and Altruism were significant predictors of Coworker Communication; and Altruism was a strong predictor of Communication Skills. No PSCOPQ variable was found to be a significant predictor of final SPEF-R performance.  https://www.selleckchem.com/mTOR.html  The findings reflect the dynamic and complex nature of professionalism in occupational therapy fieldwork settings.Introduction To assist with the professional development of physical therapists in Kenya, a post-graduate residency program was developed and implemented in the country.Purpose The purpose of this study was to explore the influence of residency training on the professional development of physical therapists.Methods The influence of the program on professional development of residents was explored through a mixed-methods research design, including a survey and semi-structured interviews with residents at program completion.Results The graduates reported a positive impact of residency education on their ability to perform a comprehensive evaluation, utilize clinical reasoning, provide an effective treatment to achieve projected outcomes, treat complex patients, communicate with patients and other health professionals, perform overall patient management, and implement a treatment plan based on scientific literature. Four themes emerged from the interviews 1) evolution of practice from protocol-driven to individualized treatment plans; 2) promotion of professional development within the wider physical therapy community; 3) positive change in physical therapy practice; and 4) commitment to lifelong learning.Conclusion The residents expressed how their new knowledge and skills fostered their commitment to providing mentorship to colleagues and lifelong learning. This commitment can provide the framework for advancing the practice of physical therapy in their respective communities.Background Cumulative evidence has demonstrated important differences between deficit (DS) and non-deficit (NDS) schizophrenia, suggesting that DS may be a separate disease. However, most data come from the same research groups and more replication is needed to validate this hypothesis.Aims Our study aimed to examine the distribution of DS, to compare their characteristics with NDS patients and to analyze the reliability of the two-factor structure of its negative symptomatology in a Spanish clinical sample.Methods Sixty clinically stabilized patients with schizophrenia were evaluated. The Schedule for the Deficit Syndrome was used for DS/NDS categorization. Patient characteristics included age, gender, education, age at onset of psychosis, duration of illness, family history of psychosis, type of antipsychotic regimen, schizophrenia subtype and severity of the disease.Results DS prevalence was 28.3%. Bivariate analysis revealed statistical differences between DS and NDS in terms of years of education and schizophrenia subtype. Factor analysis replicated the two-factor solution consisting of the 'Expressive deficit' and 'Avolition-apathy' domains reported in previous studies.Conclusions Our results were consistent with the published data and indicated that the DS profile in the Spanish population is similar to that in other populations, which would corroborate the homogeneity of DS within the schizophrenia spectrum and contribute to the hypothesis that DS constitutes a separate disease.Purpose To report the prevalence and causes of vision impairment (VI) in a population aged ≥40 years from a state-wide survey conducted in the northeastern state of Tripura, India.Methods A population-based cross-sectional study was undertaken where a sample of 4500 people was selected using cluster random sampling methodology. A team comprising of an optometrist and field workers visited the households and conducted the eye examination that included visual acuity assessment, anterior segment examination including lens and fundus examination. VI was defined as presenting visual acuity less then 6/18 in the better eye and it included moderate VI ( less then 6/18 to 6/60), severe VI ( less then 6/60 to 3/60) and blindness ( less then 3/60).Results In all, 4109/4500 (91.3%) subjects were examined from 90 clusters. Among those examined, 49.1% were men and 39.6% had no education. The age and gender-adjusted prevalence of VI was 8.7% (95% CI 7.8-9.6). The prevalence of moderate VI was 6.2% (95% CI 5.5-7.0), Severe VI was 1.0 (95% CI 0.7-1.3) and blindness was 1.5% (95% CI 1.1-1.9). On applying multiple regression analysis, the odds of having VI were higher in older age groups and among women. Overall, cataract was the leading cause of VI (54.5%) followed by uncorrected refractive errors (39.6%).Conclusions VI is common affecting nine out of every hundred people aged ≥40 years in the state of Tripura. Over 90% of which is due to avoidable causes such as cataract and uncorrected refractive errors. Provision of cataract surgery and spectacles may result in a substantial reduction in VI in Tripura.Introduction Over a decade of research and development culminated in the 2017 United States (US) Food and Drug Administration (FDA) approval of voretigene neparvovec-rzyl (VN) for RPE65 mutation-associated inherited retinal disease (IRD), the first approved gene therapy for a hereditary genetic disease in the US, and the first and only pharmacologic treatment for an IRD.Areas covered VN serves as a model for ocular gene therapy development, while RPE65 mutation-associated IRD serves as an example of a well-suited candidate disorder. This review also discusses development considerations for viral vector gene augmentation, and, studies that led to VN's FDA approval. Subretinal injection of VN resulted in improved performance on the novel multi-luminance mobility test (MLMT), light sensitivity, and visual fields in patients with RPE65 mutation-associated IRD, which predominantly impairs rod function. Additionally, the dosage, administration technique, pharmacokinetics, and safety data of VN are reviewed.Expert Opinion As a model for development, special challenges associated with the introduction of this first ocular gene therapy include limited genetic testing in clinical practice, novel surgical complexity of ocular gene therapy administration, new functional vision endpoints, as well as unique development, launch, and reimbursement considerations associated with orphan therapies and one-time gene therapies.