Dandruff is a frequently occurring scalp problem that causes significant discomfort to approximately 50% population at some stage of life, especially post-puberty and pre-adult age.
 
  This review aims to summarize the recent findings regarding the anti-fungal properties of herbal essential oils against pathogens involved in dandruff prognosis.
 
  A literature search of studies published between 2000 and 2020 was conducted over databases PubMed, Google Scholar, Scopus, and Science direct. Literature was explored using the guidelines given in Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).
 
  Dandruff, characterized by clinical symptoms of dryness, pruritis, scaly, and flaky scalp, is considered a pri-mary manifestation of seborrheic dermatitis. Amongst various etiological and pathophysiological factors, a significant role of yeasts, primarily species of Malassezia, Candida, has been strongly correlated with dandruff. At the same time, incidences of M. furfur, M. restricta, and M. globosa are high compared to others. Due to relapse of symptoms with the withdrawal of conventional anti-dandruff products. Essential oils of herbal origin, such as tea tree oil, lime oil, rose-mary oil, have gained global importance in dermatology. These oils are rich in secondary aromatic metabolites, espe-cially terpenes and phenolic components that impart substantial antimicrobial properties and resisting biofilm production.
 
  Based on the available information, we can conclude that essential oils have tremendous potential to be developed as anti-dandruff products; however, further studies are warranted to establish their efficacy in dandruff cures.
 Based on the available information, we can conclude that essential oils have tremendous potential to be developed as anti-dandruff products; however, further studies are warranted to establish their efficacy in dandruff cures.COVID-19 is considered the most challenging in the current situation. At the same time, lung cancer is also the leading cause of death in the global population and is among the top human diseases and highly complex in terms of diagnostic and therapeutic approaches and are among the most frequent and highly complex, and heterogeneous. Based on the latest update, it is known that the patients who have lung cancer are considered to be significantly at higher risk after COVID-19 infection in terms of survival, and there are a number of pieces of evidence that support the hypothesis that these diseases may share the functions and the functional components. Multi-level unwanted alterations such as (epi-)genetic alterations, changes at the transcriptional level, and altered signaling pathways (receptor, cytoplasmic, and nuclear level) are the major source which promotes a number of complex diseases, and such heterogeneous level of complexities are considered as the major barrier in the development of therapeutic. Wirk. This review and research study leads to the conclusion that growth-promoting pathways (EGFR, Ras, and PI3K), growth inhibitory pathways (p53 and STK11), apoptotic pathways (Bcl-2/Bax/Fas), and DDR pathways and genes are commonly and dominantly altered in both the cases COVID-19 and lung cancer.
  The recent Zika virus (ZIKV) outbreak provides a spur for new, efficient, and safe anti-Zika Virus agents. RNA-dependent RNA polymerase (RdRp) is critical amongst the seven non-structural proteins for viral replication and is considered an attractive drug target.
 
  In this study, a molecular docking approach was used to rationally screen the library of 5000 phytochemicals to find inhibitors against NS5 RdRp. LigX tool was used to analyze the 2D plots of receptor-ligand interactions. The top-ranked compounds were then subjected to in-silico pharmacokinetic study.
 
  The compounds, namely Polydatin, Dihydrogenistin, Liquiritin, Rhapontin, and Cichoriin, successfully bind inside the pocket of NS5 RdRp. Polydatin was the leading phytochemical that showed high docking score of -18.71 (kcal/mol) and bonding interaction at the active site of NS5 RdRp. They were subjected to analysis for drug-like properties that further reinforced their validation and showed that they could attach with the receptor more than SOFOSBUVIR control drugs. MD simulation of the top two complexes was performed, and the simulated complexes showed stability, and ligands were kept within the bonding pocket.
 
  The study might facilitate the development of a natural and cost-effective drug against ZIKV. Further validation, however, is necessary to confirm its drug effectiveness and its biocompatibility.
 The study might facilitate the development of a natural and cost-effective drug against ZIKV. Further validation, however, is necessary to confirm its drug effectiveness and its biocompatibility.
  The phenomena of rotating disks involving flows serve as a crucial element in the field of fluid mechanics. Due to its massive practical importance in engineering and industry, considerable attention is being paid to the extensions of the problems associated with rotating stretching disks. In this regard, Carbon nanotubes (CNT) are chosen as the best example of true nanotechnology. CNTs have an incredible range of applications due to their extraordinary characteristics. But single rotating-stretching disk with CNTs fluid flow has not been plowed yet.
 
  The objective of this work is to outstretch the study of a viscous fluid with carbon nanotubes (CNTs) and transfer of heat due to radially stretching and rotating disk contingent to Navier slip, nonlinear radiations, and convective boundary conditions.
 
  Cylindrical coordinates are utilized in the modeling and the mathematical formulation of the flow equations. These flow equations take the form of ordinary differential equations by means of similarity transformations. The emanated equations are solved by two numerical methods, i.e., the shooting method and the Keller box method, respectively. Xue model of carbon nanotubes is incorporated to carry out the research.
 
  The acquired solutions are tabulated, and precise values of the physical parameters with excellent matching results are shown. These results are juxtaposed with CNTs of multi-wall and single-wall carbon nanotubes, while water is taken as a base fluid.
 
  Results reveal a significant depletion in skin friction with an increase in the slip parameter.  https://www.selleckchem.com/products/ku-0060648.html  Slip, nonlinear radiation, and Biot number proved as liable factors in escalating the rate of heat transfer.
 Results reveal a significant depletion in skin friction with an increase in the slip parameter. Slip, nonlinear radiation, and Biot number proved as liable factors in escalating the rate of heat transfer.