https://www.selleckchem.com/products/bromopyruvic-acid.html Artificial intelligence (AI) in radiology has gained wide interest due to the development of neural network architectures with high performance in computer vision related tasks. As AI based software programs become more integrated into the clinical workflow, radiologists can benefit from better understanding the principles of artificial intelligence. This series aims to explain basic concepts of AI and its applications in medical imaging. In this article, we will review the background of neural network architecture and its application in imaging analysis.After fertilization, the genome of the totipotent embryo is transcriptionally inactive and then initiates bursts of transcription termed zygotic genome activation (ZGA). Despite the fundamental importance of initiating an embryonic transcription program for the start of life, the essential regulators and molecular mechanisms triggering ZGA in most organisms are poorly understood. One mechanism centers on pioneer factors that function in cellular reprogramming and differentiation. Recent studies revealed that not only a single but multiple pioneer factors bind cooperatively to the genome to open chromatin, resulting in changes in epigenetic modifications and triggering ZGA. Here, we review recent insights into the functions of pioneer factors during ZGA and discuss the potential relevance to three-dimensional chromatin organization during embryonic development. Transferring what has been learned in the classroom to clinical application is the main goal of nursing education. Our previous intervention study, in which a web-based interactive situational teaching strategy in a nursing ethic course was conducted as an experimental group, and the students in the class who were taught using a traditional teaching strategy was treated as the comparative group. The results, which were evaluated immediately after the class, showed that the web-based interactive situat