https://www.selleckchem.com/products/doxycycline.html Recalculation of all the data using the generalised gradient approximation PBE functional finds larger energy degeneracy-driven covalency in the later actinides than using hybrid DFT. Hence, we find that conclusions concerning the covalency of the An-Cl bond are dependent not only on the metric used to evaluate it, but also on the underlying electronic structure method.The anticancer drug imatinib is often involved in therapeutic drug monitoring (TDM) studies aimed at improving the treatment of several forms of leukemia and gastrointestinal stromal tumors (GIST). To further implement the TDM of imatinib in clinical practice, we developed a detection assay by using an ssDNA aptamer, which demonstrated excellent selectivity and was not affected by interference from the components of human plasma samples. The efficient binding of imatinib to the aptamer was demonstrated by means of surface plasmon resonance (SPR) analysis, which allowed the development of a quantitative assay in the concentration range between 400 and 6000 ng mL-1 (0.7-10 μM), where a lower limit of quantification (LLOQ) of 400 ng mL-1 was achieved. The precision of the assay was found to be within 12.0%, whereas the accuracy was in a range between 97.1 and 101.5%. The sample preparation procedure displayed a recovery in the range of 48.8-52.8%. Solid validation data were collected according to the regulatory guidelines and the method was compared with standard analytical techniques, leading to the development of a feasible aptasensor for the TDM of patients administered with imatinib.Preparation of a stable U(v) complex in an aqueous medium is a challenging task owing to its disproportionation nature (conversion into more stable U(vi) and U(iv) species) and sensitivity to atmospheric oxygen. The stable uranyl (UO22+)/dipicolinic acid (DPA) complex ([U(VI)O2(DPA)(OH)(H2O)]-) was formed at pH 10.5-12.0, which was confirmed by potentiometric and spect