Obesity is a chronic disease affecting women at higher rates than men. In an obstetrics and gynecology setting, frequently encountered obesity-related complications are polycystic ovary syndrome, fertility and pregnancy complications, and increased risk of breast and gynecological cancers. Obstetrician-gynecologists (OBGYNs) are uniquely positioned to diagnose and treat obesity, given their role in women's primary health care and the increasing prevalence of obesity-related fertility and pregnancy complications. The metabolic processes of bodyweight regulation are complex, which makes weight-loss maintenance challenging, despite dietary modifications and exercise. Antiobesity medications (AOMs) can facilitate weight loss by targeting appetite regulation. There are four AOMs currently approved for long-term use in the United States, of which liraglutide 3.0 mg is among the most efficacious. Liraglutide 3.0 mg, a glucagon-like peptide-1 receptor agonist (GLP-1 RA), is superior to placebo in achieving weight loss and improving cardiometabolic profile, in both clinical trial and real-world settings. In addition, women with fertility complications receiving liraglutide 1.8-3.0 mg can benefit from improved ovarian function and fertility. Liraglutide 3.0 mg is generally well tolerated, but associated with transient gastrointestinal side effects, which can be mitigated. In this review, we present the risks of obesity and benefits of weight loss for women, and summarize clinical development of GLP-1 RAs for weight management. Finally, we provide practical advice and recommendations for OBGYNs to open the discussion about bodyweight with their patients, initiate lifestyle modification and GLP-1 RA treatment, and help them persist with these interventions to achieve optimal weight loss with associated health benefits.
  The COVID-19 pandemic threatened medical teaching and progression secondary to the 'lockdown' measures which limit physical interactions. Consequently, there was a necessity to shift medical teaching and assessment online. Our challenge was to logistically organise and conduct an Objective Structured Clinical Examination (OSCE) using a virtual, socially distanced approach.
 
  We found that Zoom offered the most suitable functionality in mimicking a physical OSCE online and its breakout rooms were used to represent different stations. One organiser manually transferred candidates between stations, allowing for the OSCE to operate punctually. Examiners screen shared to display an automated slideshow with station vignettes, investigation results, and viva questions.
 
  Participants found the use of Zoom's features to be extremely beneficial with one candidate describing the experience as 'brilliant, very efficient and smooth'. Numerous aspects of the OSCE from decision making, to verbal communication, to medical knowledge were assessed, equivalent to a physical OSCE.
 
  As the transformation of medical education is catalysed by the pandemic, it is important to ensure that peer to peer teaching and assessments are revolutionised with a quality similar to that of physical teaching. We have displayed how this may be achieved in an OSCE setting using Zoom teleconferencing.
 As the transformation of medical education is catalysed by the pandemic, it is important to ensure that peer to peer teaching and assessments are revolutionised with a quality similar to that of physical teaching. We have displayed how this may be achieved in an OSCE setting using Zoom teleconferencing.Committed, long-term romantic relationships are ubiquitous among modern society. They are one of the most important contexts for the development, maintenance, and treatment of psychopathology. In this review, I first place psychopathology within the most commonly cited theoretical model of marital satisfaction and stability and then discuss how relationship satisfaction is conceptualized and assessed in this literature. In the second half of the review, I describe the theories regarding how romantic relationships may be connected to psychopathology. Relationship distress is easily incorporated into a diathesis-stress model as an important trigger for psychopathology. Next, I review cross-sectional research, longitudinal research, and treatment efficacy research linking relationship quality and psychopathology. I provide evidence for the robustness of these effects and areas where research must expand. I finish with a summary section that synthesizes what is known about the mechanisms linking relationship distress and psychopathology.We report the synthesis, crystal structure, and electronic structure calculations of a one-dimensional silver-thiolate cluster-assembled and its ultrafast spectroscopic investigation.  https://www.selleckchem.com/products/aticaprant.html  Experiments and theory find the material to have a significant gap as the HOMO-LUMO absorption corresponds to 2.69 eV, and the defect-free structure is calculated to have a gap of 2.82 eV. Cluster models demonstrate that the gap energy is length-dependent. Theoretical studies identify a nonbonding metallophilic interaction that exists between two Ag atoms in adjacent strings that helps to stabilize the chain structure. Transient absorption spectroscopy reveals that the electron dynamics is a mixture of the behavior of cluster and nanoparticle, with the material having a 346 fs ground-state relaxation like a cluster, and the electron dynamics is dominated by electron-phonon coupling with a decay time of 1.5 ps, unlike the isolated cluster whose decay is mostly radiative.An efficient and atom-economical palladium-catalyzed intramolecular cross dehydrogenative coupling (CDC) reaction has been developed for the construction of highly π-conjugated benzimidazo[1,2-a]quinoline-fused isoxazole scaffolds using molecular oxygen as sole oxidant. The approach portrayed wide substrate scope with good functional group tolerance and depicted a useful tool for the generation of fluorescence active compounds with high quantum yield. Synthetic versatility of the method via Fe-catalyzed reductive isoxazole ring cleavage toward pyridine, pyrimidine, pyrazole fused heteropolycyclic compounds has been showcase.