https://www.selleckchem.com/products/rin1.html 2 N/mm P = 0.009, 26.7 ± 5.2 N/mm vs 19.4 ± 5.2 N/mm P less then 0.001). Improved bone-tendon interface histological maturity scores (14.8 ± 0.9 vs 8.2 ± 1.5 P = 0.027, 16.8 ± 0.7 vs 10.5 ± 1.4 P = 0.027) and large metachromasia areas (0.117 ± 0.053 mm2 vs 0.032 ± 0.017 mm2P = 0.022, 0.14 ± 0.046 mm2 vs 0.037 ± 0.016 mm2P = 0.007) were obtained in the preservation group compared with the removal group at 4 and 12 weeks. CONCLUSIONS The present study showed that preserving remnant tissue in anatomical repair can significantly improve rotator cuff healing compared with remnant tissue removal on footprint in terms of biomechanical properties, bone-tendon interface histological maturity scores and metachromasia at 4 and 12 weeks post-repair in a rotator cuff tear rabbit model. As one of the most widespread environmental pollutants, benzo[α]pyrene is metabolized to diol epoxides and then covalently breaks the initial DNA base pairs, which has been closely related to the occurrence and development of many human cancers. High fidelity DNA polymerases play an extremely important role in maintaining the reliability or fidelity of nucleic acid replication, which is generally blocked by BP adducts. To reveal the blocking mechanism of BP, two comparative molecular dynamics simulations were performed for the thermophilic Bacillus stearothermophilus DNA polymerase I large fragment (BF) complexes with normal and BP-bound DNA duplexes. The results of global conformational changes and molecular interactions show that the association of BP leads to the rearrangement of intramolecular hydrogen bonds, impairing the molecular recognition between the polymerase and the DNA duplex. It is also found that the conformation of DNA duplex is distorted, accompanied by an increase in molecular overall rigidity. In terms of possible blocking mechanisms, the BP moiety perfectly integrates itself into the base-paired environment in a special vertical c