https://www.selleckchem.com/products/gcn2-in-1.html Ca and P were increased after remineralization in all groups. Between groups, the increase was more for ReminPro, followed by Clinpro and MI. In this study, the remineralizing potential of Remin Pro was effectively more, followed by Clinpro and MI. In this study, the remineralizing potential of Remin Pro was effectively more, followed by Clinpro and MI. The present study was carried out with the objective of evaluation of efficacy of two root canal irrigants (LARGAL ULTRA and Biopure mixture of tetracycline, acid, and detergent [MTAD]) in smear layer removal and sealer penetration along the canal walls and to apprise any change in their efficacy when they were activated with two different types of lasers (neodymium-doped yttrium aluminum garnet [NdYAG] and erbium-doped yttrium aluminum garnet [ErYAG]). The analysis was done with the help of confocal laser scanning microscope. The curved root canals (>20°) from 140 extracted human molars (negative control, = 20) were prepared to size #25.06 with NaOCl irrigation. Teeth were divided into two experimental groups with sample size 60 each (Group I, II). Groups further divided into subgroups IA, IB, and IC and IIA, IIB, and IIC with sample size twenty each. Group IA, Largal Ultra irrigation without LAI; Group IB, Largal Ultra irrigation with NdYAG; Group IC, Largal ultra with ErYAG; Group IIA, MTAD irrigon, with ErYAG laser being more potent than NdYAG laser. It was inferred that, among the two irrigating solutions tested, Biopure MTAD is more proficient than Largal Ultra. Laser activation of final irrigating solution has been shown to allow better sealer penetration, with ErYAG laser being more potent than NdYAG laser. The aim was to compare and evaluate the efficacy of electrochemically activated water (ECA) against maleic acid, Mixture of tetracycline, acid and detergent. ie; 3% doxycycline, 4.25% citric acid, and 0.5% Tween 80 detergent (MTAD), Sodium hypochlorite (N