https://www.selleckchem.com/products/1-deoxynojirimycin.html The waste collection routing problem (WCRP) can be defined as a problem of designing a route to serve all of the customers (represented as nodes) with the least total traveling time or distance, served by the least number of vehicles under specific constraints, such as vehicle capacity. The relevance of WCRP is rising due to its increased waste generation and all the challenges involved in its efficient disposal. This research provides a mini-review of the latest approaches and its application in the collection and routing of waste. Several metaheuristic algorithms are reviewed, such as ant colony optimization, simulated annealing, genetic algorithm, large neighborhood search, greedy randomized adaptive search procedures, and others. Some other approaches to solve WCRP like GIS is also introduced. Finally, a performance comparison of a real-world benchmark is presented as well as future research opportunities in WCRP field.High-dose methotrexate (HDMTX) is an important component of treatment in pediatric acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LL). Optimal rescue therapy is essential for the safe administration of HDMTX. A cost-effective strategy that does not compromise safety is necessary for low- and middle-income countries. Consecutive admissions for HDMTX in children with ALL and LL over 12 months were analyzed. The dose of HDMTX was 3 g/m2 in B-ALL and B-LL and 5 g/m2 in T-ALL and T-LL. A methotrexate level was measured at 42 hours of starting HDMTX infusion (T42-MTX). Three doses of folinic acid at T42, T48, and T54 and alkalinized hydration till T54 were administered if T42-MTX less then 1 µM. A total of 282 cycles of HDMTX that were administered in 71 patients were analyzed. T42-MTX was less then 1 µM in 266 (94.3%) cycles. T42-MTX was ≥1 µM in 12% and 3% of cycles of HDMTX administered at a dose of 5 g/m2 and 3 g/m2, respectively (p = .074). The median duration of hospitali