The two clinical groups used words expressing suicidal intent, whereas the healthy group did not. CONCLUSIONS Therapists are encouraged not to underestimate suicidal ideation in NSSI regardless of whether or not they have already attempted suicide. © 2020 The American Association of Suicidology.Lymphocytes such as T-cells can be genetically transduced to express a synthetic chimeric antigen receptor (CAR) that re-directs their cytotoxic activity against a tumour-expressed antigen of choice. Autologous (patient-derived) CAR T-cells have been licensed to treat certain relapsed and refractory B-cell malignancies, and numerous CAR T-cell products are in clinical development. As living gene-modified cells, CAR T-cells exhibit unique pharmacokinetics, typically proliferating within the recipient during the first 14 days after administration before contracting in number, and sometimes exhibiting long-term persistence. The relationship between CAR T-cell dose and exposure is highly variable, and may be influenced by CAR design, patient immune function at the time of T-cell harvest, phenotype of the CAR T-cell product, disease burden, lymphodepleting chemotherapy and subsequent immunomodulatory therapies. Recommended CAR T-cell doses are typically established for a specific product and indication, although for some products, stratification of dose based on disease burden may mitigate toxicity while maintaining efficacy. Re-evaluation of CAR T-cell dosing may be necessary following changes to the lymphodepleting regimen, for different disease indications, and following significant manufacturing changes, if product comparability cannot be demonstrated. Dose escalation trials have typically employed 3 + 3 designs, although this approach has limitations, and alternative phase I trial designs may facilitate the identification of CAR T-cell doses that strike an optimal balance of safety, efficacy and manufacturing feasibility. © 2020 The British Pharmacological Society.BACKGROUND The number of refugees worldwide has increased in recent years and with this, there has been an increase in the numbers of Unaccompanied Asylum Seeking Minors (UASMs) in the UK. Refugees have been found to experience notable difficulties upon resettlement and there is evidence to suggest that education can provide a supportive role for young refugees. Although there has been research that has found that UASMs value education, there has been less research that has directly looked at the experiences of education for UASMs. METHODS In the present study, six UASMs were interviewed and Interpretative Phenomenological Analysis (IPA) was used as a methodology to analyse the data. RESULTS Five themes were identified Education facilitating socialising; Education and English proficiency leading to a better life in the UK; the impact of transitions; the impact of external stressors; and a desire for additional resources to learn at one's own pace. CONCLUSIONS Participants within the present research expressed a strong desire for additional resources that would allow them to learn at their own pace. They also emphasised how transitions between different settings and external stressors had an impact on their experiences of education. The links between coping strategies and the participant's asylum status are also discussed with reference to relevant research in the field. This article is protected by copyright. All rights reserved.PURPOSE The Monte Carlo radiation transport method is considered the most accurate approach for absorbed dose calculations in external beam radiation therapy. In this study, an efficient and accurate source model of the Varian TrueBeam 6X STx Linac is developed and integrated with a fast Monte Carlo photon-electron transport absorbed dose engine, ARCHER-RT, which is capable of being executed on CPUs, NVIDIA GPUs and AMD GPUs. This capability of fast yet accurate radiation dose calculation is essential for clinical utility of this new technology. This paper describes the software and algorithmic developments made to the ARCHER-RT absorbed dose engine. METHODS AMD's Heterogeneous-Compute Interface for Portability (HIP) was implemented in ARCHER-RT to allow for device independent execution on NVIDIA and AMD GPUs. Architecture specific atomic-add algorithms have been identified and both more accurate single precision and double precision computational absorbed dose calculation methods have been added to ARCHER-RTat Monte Carlo based absorbed dose engines like ARCHER-RT have the potential for widespread clinical implementation. This article is protected by copyright. All rights reserved.AIM To provide insights into how workplace violence has an impact on nurses and to inform human resource management about developing comprehensive strategies to manage and mitigate violence. DESIGN A systematic review of the literature to appraise contemporary studies, source data and synthesise findings for human resource management to implement practices to mitigate violence against nurses in the healthcare sector. DATA SOURCES Searches were conducted using ProQuest, Business Source Complete (EBSCO), Emerald Insight, PsycINFO (ProQuest), ScienceDirect and Google Scholar.  https://www.selleckchem.com/products/3-deazaneplanocin-a-dznep.html  Our search was delimited to refereed journal articles and government reports over the last fifteen years from 2004 - 2019 and included a total of 71 articles. REVIEW METHODS The research team systematically reviewed each article and relative reports, eliminating any not considered relevant to nurses. This systematic review is associated with and reflects contemporary issues around nurses, violence and human resource management practice. RESed.5-methoxycanthin-6-one, a major canthinone alkaloid isolated from Picrasma quassioides, exhibited significant pharmacological activities. In this study, a rapid and sensitive LC-MS/MS method was established and validated for the determination of 5-hydroxy-4-methoxycanthin-6-one in rat plasma. Small quantities (20 μL) of plasma sample were used for sample preparation. 5-Hydroxy-4-methoxycanthin-6-one and an internal standard (IS, caffeine) were separated using an ACQUITY HSS T3 column (50 × 2.1 mm, 1.7 μm; Waters, Milford, MA, USA). The mobile phase was composed of 0.1% formic acid in water and acetonitrile. Precursor-to-product ion transitions were m/z 267.0 → 168.2 and m/z 195.0 → 138.1 for quantitative monitoring of 5-hydroxy-4-methoxycanthin-6-one and IS, respectively. The assay was linear over the concentration range of 0.5-500 ng/mL (r > 0.99) with the lower limit of quantification 0.5 ng/mL. Other parameters, including intra- and inter-day precision and accuracy, carryover, stability, extraction recovery, matrix effect, and dilution effect, were within acceptable limits.