https://www.selleckchem.com/products/seclidemstat.html Results Oxygen saturation decreased during ascent to 1,500 m (-2%) and 3,000 m (-8%), compared with sea level. Handgrip MVC was not affected by altitude, although heart rate at rest (∼70 beat/min), during static exercise (range ∼90-95 beat/min), and during recovery in both conditions (each ∼70 beat/min) was significantly increased by ∼15% at 3,000 m, but not 1,500 m. The magnitude of the muscle metaboreflex during recovery from static exercise was unaffected by altitude; however, the rate-pressure product was significantly elevated by ∼10% during and following static exercise at 3,000 m. Conclusions A significant increase in the rate-pressure product during static exercise was observed at altitude, which persisted during recovery. Individuals at risk for cardiac events should use awareness of static contractions while at altitude, especially considering that stress induced by static exercise is additive to that of dynamic activities such as hiking.The coronavirus disease 2019 (COVID-19) pandemic has created substantial challenges for public health officials who must communicate pandemic-related risks and recommendations to the public. Their efforts have been further hampered by the politicization of the pandemic, including media outlets that question the seriousness and necessity of protective actions. The availability of highly politicized news from online platforms has led to concerns about the notion of "echo chambers," whereby users are exposed only to information that conforms to and reinforces their existing beliefs. Using a sample of 5,000 US residents, we explored their information-seeking tendencies, reliance on conservative and liberal online media, risk perceptions, and mitigation behaviors. The results of our study suggest that risk perceptions may vary across preferences for conservative or liberal bias; however, our results do not support differences in the mitigation behavior across patterns of me