https://www.selleckchem.com/products/AC-220.html Understanding how stem cells adapt to space flight conditions is fundamental for human space missions and extraterrestrial settlement. We analyzed gene expression in boundary cap neural crest stem cells (BCs), which are attractive for regenerative medicine by their ability to promote proliferation and survival of cocultured and co-implanted cells. BCs were launched to space (space exposed cells) (SEC), onboard sounding rocket MASER 14 as free-floating neurospheres or in a bioprinted scaffold. For comparison, BCs were placed in a random positioning machine (RPM) to simulate microgravity on earth (RPM cells) or were cultured under control conditions in the laboratory. Using next-generation RNA sequencing and data post-processing, we discovered that SEC upregulated genes related to proliferation and survival, whereas RPM cells upregulated genes associated with differentiation and inflammation. Thus, (i) space flight provides unique conditions with distinctly different effects on the properties of BC compared to earth controls, and (ii) the space flight exposure induces postflight properties that reinforce the utility of BC for regenerative medicine and tissue engineering.The COVID-19 pandemic and the associated infection prevention and control measures (e.g. quarantine, lockdown and isolation), have had an adverse impact on mental health. To date, the mental health status and challenges of foreign workers during the pandemic have been neglected in the literature. This cross-sectional web-based survey assessed levels of post-traumatic stress, depression, anxiety and insomnia among an international sample of foreign workers (n = 319) resident in the United Arab Emirates (UAE). The majority of participants were female (76%), European (69%) and highly educated (83% had a bachelor's or higher degree). Results indicate high rates of post-traumatic stress, depression, anxiety, and insomnia, especially among women, younger indiv