https://www.selleckchem.com/products/ono-ae3-208.html The series of highly stable porous solids here feature systematic, regiospecific sulfur substitutions on the organic linkers for versatile functions. One major surprise lies in the controllable sequential reactions between sodium thiomethoxide (NaSMe) and octafluorobiphenyl-4,4'-dicarboxylic acid (H2bpdc-8F; this was readily made without precious metal catalysts). Namely, 3, 4, 6, and 8 methylthio-substitutions can be respectively achieved with regiospecificity (i.e., to produce the four molecules H2bpdc-3S5F, H2bpdc-4S4F, H2bpdc-6S2F, H2bpdc-8MS). A second surprise lies in their persistent formation of the UiO-67-type net with Zr(IV) ions, e.g., even in the case of the fully sulfurated H2bpdc-8MS. In addition to the remarkable breadth of functional control, all the Zr(IV)-based crystalline solids here are stable in boiling water (e.g., for 24 h) and in air as solventless, activated porous solids. Moreover, the thioether groups allow for convenient H2O2 oxidation to fine-tune the hydrophilicity and luminescence properties and improve proton conductivity.A new design of microelectrode was introduced to generate electrochemically steady-state linear concentration gradients perpendicular to the flow direction throughout the cross section of microchannels. The shape and geometry of the electrode were established based on operating regimes at microchannel electrodes. Before implementation, optimal conditions were preliminary delineated by numerical simulations according to the flow velocity and microchannel dimensions. To assess experimentally these predictions, a specific microfluidic platform was developed with optimized geometry to simultaneously allow the generation of linear concentration gradients and the mapping of concentration profiles by confocal fluorescence microscopy. As a model, the electrochemical reduction of a quinone in the presence of fluorescein was selected to both generate and monitor a linear pr