https://www.selleckchem.com/products/a-485.html Background Differences in imaging parameters influence computer-extracted parenchymal enhancement measures from breast MRI. Purpose To investigate the effect of differences in dynamic contrast-enhanced MRI acquisition parameter settings on quantitative parenchymal enhancement of the breast, and to evaluate harmonization of contrast-enhancement values with respect to flip angle and repetition time. Study type Retrospective. Phantom/populations We modeled parenchymal enhancement using simulations, a phantom, and two cohorts (N = 398 and N = 302) from independent cancer centers. Sequence field/strength 1.5T dynamic contrast-enhanced T1 -weighted spoiled gradient echo MRI. Vendors Philips, Siemens, General Electric Medical Systems. Assessment We assessed harmonization of parenchymal enhancement in simulations and phantom by varying the MR parameters that influence the amount of T1 -weighting flip angle (8°-25°) and repetition time (4-12 msec). We calculated the median and interquartile range (IQR) of the enhancemap). Data conclusion The proposed practical harmonization method enables an accurate comparison between patients scanned with differences in imaging parameters. Level of evidence 3 TECHNICAL EFFICACY STAGE 4.Aim The aim of the study is to investigate the efficiency of Geotrichum candidum in the decolorization and mineralization of synthetic azo dyes. Methods and results It includes screening of enzymes from G. candidum and its optimization, followed by decolorization and mineralization studies. Decolorization was observed to be maximum in methyl orange (94.6%) followed by congo red (85%), trypan blue (70.4%) and eriochrome black t (55.6%) in 48h, suggesting the plausible degradation of the azo dyes by G. candidum. The enzyme activity study showed that DyP-type peroxidase has highest activity of 900 mU ml-1 compared to that of laccase (405 mU ml-1 ) and lignin peroxidase (324 mU ml-1 ) at optimized pH (6) and temper