Following the actual dropout people involving neoadjuvant radiation treatment with in the area superior oral cavity most cancers. 05). The BLS knowledge among young doctors in India is very low as evidenced by poor performance in the pretest. Regular BLS courses are necessary to improve the knowledge among them and to prepare them to respond to a medical emergency. Knowledge and skills pertaining to BLS are not usually taught in medical schools in India. This study indicates the lack of knowledge among medical students about BLS and the need for improvement and regular update. This study can serve as a guide for policymakers to consider inculcating BLS knowledge into the medical school curriculum in the near future. Vineeth Chandran K, Abraham SV. Basic Life Support Need of the Hour-A Study on the Knowledge of Basic Life Support among Young Doctors in India. Indian J Crit Care Med 2020;24(5)332-335. Vineeth Chandran K, Abraham SV. Basic Life Support Need of the Hour-A Study on the Knowledge of Basic Life Support among Young Doctors in India. Indian J Crit Care Med 2020;24(5)332-335. Although high procalcitonin (PCT) levels are associated with poor neurological outcomes and increased mortality rates in patients treated with targeted temperature management (TTM) in the postcardiac arrest (CA) period, there are limited data about the correlation between PCT levels and infection. The aim of our study was to assess the relationship of PCT levels in the first 48 hours with early period infections, late period neurological prognosis, and mortality in patients treated with TTM after CA. Serum PCT was measured on admission days 1 and 2. The early onset infection diagnosis before the seventh day in the intensive care unit (ICU) was made according to the criteria of infection centers for disease control and prevention. Mortality and neurologic outcomes were assessed 90 days after CA according to cerebral performance category (CPC) score. There was no statistically significant correlation between early period infection diagnosis and PCT levels at the time of admission, 24th, and 48th hours. Paa Marker of Neurologic Outcome or Early Infection in Patients Treated with Targeted Temperature Management? Indian J Crit Care Med 2020;24(5)327-331. Early goal-directed therapy (EGDT) provides preset goals to be achieved by intravenous fluid therapy and inotropic therapy with earliest detection of change in the hemodynamic profile. Improved outcome in cardiac surgery patients has been shown by perioperative volume optimization, while postoperative intensive care unit (ICU) stay can be decreased by improving oxygen delivery. Our aim of this study was to study the outcome of EGDT in patients undergoing elective cardiac surgery. This is a prospective single institute study involving a total of 478 patients. https://www.selleckchem.com/products/kpt-8602.html Patients were divided into group I, who received standard hospital care, and group II, who received EGDT. Postoperatively, patients were observed in ICU for 72 hours. Hemodynamics, laboratory data, fluid bolus, inotrope score, complication, ventilatory time, and mortality data were collected. Postoperative ventilatory period (11.12 ± 10.11 vs 9.45 ± 8.87, = 0.0719) and frequency of change in inotropes (1.900 ± 0.9 vs 1.19 ± 0.61, = 0.0717) werre Med 2020;24(5)321-326. Nontraumatic undifferentiated hypotension is one of the common and challenging critical presentations in the emergency department (ED) due to the difficulty in diagnosing the etiology of shock. In the present study, an attempt was made to test point-of-care ultrasound (PoCUS) as an early approach to improve the accuracy of diagnosis and to narrow the differentials in cases of nontraumatic undifferentiated hypotension. This is a prospective explorative study conducted in the ED of a tertiary care hospital over a period of 18 months. A total of 100 patients were included in the study. https://www.selleckchem.com/products/kpt-8602.html All patients >18 years of age with systolic blood pressure <90 mm Hg with at least one sign or symptom of hypoperfusion were included in the study. Patients referred from another hospital as shock, history of trauma, and history suggestive of orthostatic hypotension and presented with symptomatic postural hypotension as the only chief complaint were excluded. All the patients who met the inclusion/exclusion criteria unded Hypotension. Indian J Crit Care Med 2020;24(5)313-320. Javali RH, Loganathan A, Srinivasarangan M, Akkamahadevi P, Ganesha BS, Nisarg S, et al. Reliability of Emergency Department Diagnosis in Identifying the Etiology of Nontraumatic Undifferentiated Hypotension. Indian J Crit Care Med 2020;24(5)313-320. During identification and diagnosis, typhoid fever (TF) causes various issues such as nonspecific symptoms and nontyphoidal associated febrile diseases. Accurate identification and diagnosis are still a substantial concern. The current study was undertaken to study the clinical profile of TF and the role of Typhifast IgM and Enterocheck WB in early diagnosis. Clinically suspected TF patients (121) were included in the study. Patients with antibiotic history during the period of febrile illness were excluded. The diagnosis was confirmed with blood culture test. Widal test and two new rapid serological tests Typhifast IgM and Enterocheck WB were performed. The outcomes were compared with blood culture-confirmed cases to derive the sensitivity and specificity of the diagnostic tests. The clinical characteristics were compared with diagnostic tests using Chi-square test. The most common presentations of TF were fever, chills, vomiting, abdominal pain, anorexia, constipation, and diarrhea. Among the 121 clcheck WB in the Diagnosis of Typhoid Fever. Indian J Crit Care Med 2020;24(5)307-312. To assess the quality of life (QoL) following intensive care unit (ICU) discharge using 6 months' prospective follow-up and to analyze the risk factors affecting quality-of-life post-discharge. A prospective observational cohort study. Conducted on adult patients, discharged from ICU after more than 7 days' stay. Study duration is from January 2017 to October 2018. Patients <18 years, nonconsenting, preexisting neurological illness, and lost to follow-up were excluded. Follow-up was done at 1 and 6 months using the SF-36 questionnaire. The pre-ICU functional status, patient demographics, sequential organ failure assessment (SOFA) score, acute physiology and chronic health evaluation (APACHE II) score, New York Health Evaluation (NYHA) classification, and details of ICU stay were collected. One hundred patients (M = 60, F = 40) with ICU stay (13.64 ± 3.75 days), days of mechanical ventilation (7.93 ± 3.89 days), admission APACHE II (18.88 ± 4.34) and SOFA (7.73 ± 1.54) scores. Comparison showed physical component summary (PCS) score and mental component summary (MCS) score at pre-ICU were 55.