https://www.selleckchem.com/products/a-d-glucose-anhydrous.html Delivering linguistically competent care is critical to serving limited English proficiency (LEP) patients, and represents a key national strategy to help reduce health disparities. Current acceptable standards of communication with LEP patients include providers communicating through professional interpretive services, or bilingual providers speaking the patients' preferred language directly. This randomized clinical trial tests the impact of patient-provider language concordance on patient satisfaction. Eighty-three adult Spanish-speaking cancer patients were randomized to receive care from either 1) a bilingual physician speaking to the patient directly in Spanish or 2) the same physicians speaking English and using a professional interpreter service. Validated questionnaires were administered to assess patient-reported satisfaction with both provider communication and overall care. Transcripts of initial consultations were analyzed for content variations. Compared to patients receiving care through sh arm were more likely to initiate unprompted speech (mean utterances 11 vs 3.1, p<0.001), and asked their providers more questions (mean utterances 11 vs 4, p=0.007). This study demonstrates improved patient-reported satisfaction among LEP cancer patients cared for in direct Spanish compared to interpreter-based communication. Further research into interventions to mitigate this patient-provider language barrier is necessary to optimize care for this minority population. This study demonstrates improved patient-reported satisfaction among LEP cancer patients cared for in direct Spanish compared to interpreter-based communication. Further research into interventions to mitigate this patient-provider language barrier is necessary to optimize care for this minority population. As a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), osimertinib has a powerful ability t