https://www.selleckchem.com/products/reversine.html Regression analysis of variables demonstrated there was no significant relationship between the demographic variables and macular CVI. However, the analysis demonstrated age and CVI of the peripapillary area were significantly correlated. Further stratification revealed significantly higher CVI in the optic disc in subjects over 45. Peripapillary CVI in all quadrants is higher than macular CVI in all age groups. CVI significantly increases after the age of 45 in the peripapillary area but not macular area. This suggests that stromal area decline is greater than the decline of the luminal area in the choroid at the peripapillary area as age increases. Peripapillary CVI in all quadrants is higher than macular CVI in all age groups. CVI significantly increases after the age of 45 in the peripapillary area but not macular area. This suggests that stromal area decline is greater than the decline of the luminal area in the choroid at the peripapillary area as age increases. Vernal Keratoconjunctivitis is a chronic bilateral seasonally exacerbated allergy affecting the conjunctiva and cornea of children. As technology has advanced, newer medications have been developed for the control of the disease. To assess the effectiveness of an immunomodulator, cyclosporine, in the treatment of vernal keratoconjunctivitis. Fifty patients of moderate, severe to very severe vernal keratoconjunctivitis were selected for the study. They were given cyclosporine 0.05% eye drops in loading dose followed by gradual tapering. Symptoms and signs were recorded at presentation, after two weeks, after four weeks, after two months and after three months. Vernal keratoconjunctivitis, being a chronic disease showed marked improvement with immunomodulator therapy. There was significant improvement in the symptom and sign score initially, at the first follow up itself with symptom score reduction from median of mean of 2.4 to 0.6 (p=0.00) and a simil