in MS is worrying, such as the cause-consequence relationship between UTIs and the use of corticosteroids in outbreaks. Therefore, it is important to be aware of a UTI in this group to make early diagnoses, adequate management, and new infections prevention. Thus, further studies are needed to thoroughly analyze each nuance of this important comorbidity for MS patients. UTI represents a great risk and concern in MS patients. The high prevalence, hospitalization rate, and mortality rate of UTI in MS is worrying, such as the cause-consequence relationship between UTIs and the use of corticosteroids in outbreaks. Therefore, it is important to be aware of a UTI in this group to make early diagnoses, adequate management, and new infections prevention. Thus, further studies are needed to thoroughly analyze each nuance of this important comorbidity for MS patients.This paper investigates the impact of the Stepping Stones Creating Futures (SSCF) intervention on young women in informal settlements in eThekwini, South Africa. Specifically, whether following participation in the intervention the young women experienced a reduction in intimate partner violence, strengthened agency and shifted gender relations. Where changes occurred, it examines how they occurred, and barriers and enablers to change. SSCF is a gender transformative and livelihoods strengthening intervention using participatory, reflective small groups. Qualitative research was undertaken with fifteen women participating in the SSCF randomised control trial between 2015 and 2018. The women were followed over 18 months, participating in in-depth interviews at baseline, 12- and 18-months post intervention. To supplement these, eight women were involved in Photovoice work at baseline and 18 months and seven were included in ongoing participant observation. Data were analysed inductively. https://www.selleckchem.com/products/jib-04.html Data revealed many womel settlements and are critical for policy and intervention science to reduce IPV and support women's agency. CONKO-006 was designed for patients with pancreatic adenocarcinoma with postsurgical R1 residual status to evaluate the efficacy and safety of the combination of gemcitabine and sorafenib (GemSorafenib) compared with those of gemcitabine+placebo (GemP) for 12 cycles. This randomised, double-blind, placebo-controlled, multicenter study was planned to detect an improvement in recurrence-free survival (RFS) from 42% to 60% after 18 months. Secondary objectives were overall survival (OS), safety and duration of treatment. 122 patients were included between 02/2008 and 09/2013; 57 were randomised to GemSorafenib and 65 to GemP. Patient characteristics were wellbalanced (GemSorafenib/GemP) in terms of median age (63/63 years), tumour size (T3/T4 97/97%), and nodal positivity (86/85%). Grade 3/4 toxicities comprised diarrhoea (GemSorafenib 12%; GemP 2%), elevated gamma-glutamyl transferase (GGT) (19%; 9%), fatigue (5%; 2%) and hypertension (5%; 2%), as well as neutropenia (18%; 25%) and thrombocytopenia (9%; 2%). By August 2017, 118 (97%) RFS event had occurred. There were no difference in RFS (median GemSorafenib 8.5 versus GemP 9.4 months; p=0.730) nor OS (median GemSorafenib 17.6 versus GemP 17.5 months; p=0.481). Landmark analyses suggest that patients who received more than six cycles of postoperative chemotherapy had significantly longer OS (p=0.021). CONKO-006 is the first randomised clinical trial to include exclusively patients with PDAC with postsurgical R1 status thus far. Sorafenib added to gemcitabine did neither improve RFS nor OS. However, postoperative treatment exceeding six months seemed to prolong survival and should be further investigated in these high-risk patients. German Tumor Study Registry (Deutsches Krebsstudienregister), DRKS00000242. German Tumor Study Registry (Deutsches Krebsstudienregister), DRKS00000242. To investigate the relationship between one eccentric and two isometric tests commonly used to assess hamstring strength in professional soccer. Professional soccer club. Cross-sectional study. Twenty male professional soccer players. Hamstring force was quantified during 3 tests (Nordic hamstring eccentric, 9020 isometric posterior-chain strength and isometric 15° knee flexion) using a load cell, a handheld dynamometer and a force platform, respectively. Poor relationships and low concordance were observed between isometric and eccentric tests, showing different ability to discriminate hamstring weakness and asymmetries. The Nordic hamstring test identified between-limb asymmetry >15% in 30% of the players, 25% in the 15° knee flexion and 5% in the 9020 test. All players obtained different results in the three tests with only one showing asymmetry >15% in two tests. Results obtained in each test cannot inform the others. Mechanical outputs of these tests must be used for particular purposes during the prevention, rehabilitation and monitoring process of hamstring injury. Isometric testing might be preferable during the initial phases of the recovery process of a hamstring injury while the Nordic hamstring test might be used in the last stages or detect muscle weakness/asymmetries in non-injured players. Results obtained in each test cannot inform the others. Mechanical outputs of these tests must be used for particular purposes during the prevention, rehabilitation and monitoring process of hamstring injury. Isometric testing might be preferable during the initial phases of the recovery process of a hamstring injury while the Nordic hamstring test might be used in the last stages or detect muscle weakness/asymmetries in non-injured players. To investigate whether ankle joint laxity alone influences lower limb kinematics during a side-cutting task. A cross-sectional study. Sports medicine research laboratory. In total, 66 male collegiate soccer players with history of ankle sprains with no perceived ankle instability were categorised into three groups no-laxity copers (n=26), laxity copers (n=23), and severe-laxity copers (n=17). The hip, knee, ankle, rearfoot, midfoot, and forefoot kinematic data during the stance phase (0%-100% indicated initial contact to take-off) of a 45° side-cutting task were analysed using one-dimensional statistical parametric mapping. The horizontal plane kinematics of the rearfoot differed significantly among the three groups during 30%-91% of the stance phase (P<.05). Severe-laxity copers exhibited a greater external rotation angle than no-laxity copers during 6%-14% and 32%-92% of the stance phase (P<.05). Our data suggest that severe ankle joint laxity affects rearfoot horizontal plane kinematics in individuals without perceived ankle instability performing a 45° side-cutting task.