https://www.selleckchem.com/products/pkc-theta-inhibitor.html Intrinsically disordered proteins (IDPs) have no fixed tertiary structure under physiological conditions and are associated with many human diseases. Because IDPs have the characteristic of possessing diverse conformations, current experimental methods cannot capture all the conformations of IDPs. However, molecular dynamics simulation can sample these atomistically diverse conformations as a valuable complement to experimental data. To accurately describe the properties of IDPs, the environment-specific precise force field (ESFF1) was successfully released to reproduce the conformer character of ordered and disordered proteins. Here, three typical IDPs and thirteen folded proteins were used to further evaluate the performance of this force field. The results indicate that the NMR observables of ESFF1 better approach experimental data than do those of ff14SB for IDPs. The sampling conformations by ESFF1 are more diverse than those of ff14SB. For folded proteins, these force fields have comparable performances for reproducing conformers. Therefore, ESFF1 can be used to reveal the model of sequence-disorder-function for IDPs. To determine the role of sleep quality and caffeinated beverage consumption in the effect of late chronotype on body mass index (BMI). The study consisted of a total of 661 healthy university students with a mean age of 21.4 ± 1.38 years. Within the scope of the study, The Morningness-Eveningness Questionnaire (MEQ) was used to determine the chronotypes of individuals, the Pittsburgh Sleep Quality Index (PSQI) was used to determine sleep quality, and a 24 h physical activity record was taken to determine physical activity levels. The caffeine intake of the individuals was determined using a food frequency questionnaire for the intake of caffeinated food and beverages. The role of mediators in the effect of late chronotype on BMI was evaluated via multiple mediation analysis. In this st