https://www.selleckchem.com/products/ginkgolic-acid-s9432.html Headache is a common problem in primary care and one of the main reasons general practitioners consult the neurology service. We developed an online adult headache guideline for the greater Wellington Region as a resource for general practitioners to guide identification of concerning headaches, initiation of prophylactic medications for migraine, and management of analgesic overuse headache. We examined the effectiveness of this guideline in reducing demand on the neurology outpatient service for headache patients that could readily be managed in primary care. We reviewed electronic referrals to Wellington Hospital's neurology department before and after the implementation of the online headache guideline. The primary outcome was the proportion of referrals for headache. Secondary outcomes included proportion of referrals requiring clinic review, rate of pre-referral trial of headache prophylactic medication, and medication overuse headache diagnosed at neurological consultation. Nine hundred neurologyruse. This article is protected by copyright. All rights reserved.The substrate scope of sulfoxide-containing magnetisation transfer catalysts is extended to hyperpolarize α-ketoisocaproate and α-ketoisocaproate-1-[13 C]. This is achieved by forming [Ir(H)2 (κ2 -ketoisocaproate)(N-heterocyclic carbene)(sulfoxide)] which transfers latent magnetism from p-H2 via the signal amplification by reversible exchange (SABRE) process. The effect of polarization transfer field on the formation of enhanced 13 C magnetization is evaluated. Consequently, performing SABRE in a 0.5 μT field enabled most efficient magnetisation transfer. 13 C NMR signals for α-ketoisocaproate-1-[13 C] in methanol-d4 are up to 985-fold more intense than their traditional Boltzmann derived signal intensity (0.8 % 13 C polarisation). Single crystal X-ray diffraction reveals the formation of the novel catalyst decomposition products [Ir(μ-H)(H)