The Mazor family (32%) and ROSA (26%) robots were most commonly reported among robot users. Our study provides a worldwide overview of neurosurgical adoption of robotic technology. Almost half of the surveyed neurosurgeons reported having clinical experience with at least one robotic system. Ongoing and future trials should aim to clarify superiority or non-inferiority of neurosurgical robotic applications and balance these potential benefits with considerations on acquisition and maintenance costs.One of the major sources of uncertainty in large-scale crop modeling is the lack of information capturing the spatiotemporal variability of crop sowing dates. Remote sensing can contribute to reducing such uncertainties by providing essential spatial and temporal information to crop models and improving the accuracy of yield predictions. However, little is known about the impacts of the differences in crop sowing dates estimated by using remote sensing (RS) and other established methods, the uncertainties introduced by the thresholds used in these methods, and the sensitivity of simulated crop yields to these uncertainties in crop sowing dates. In the present study, we performed a systematic sensitivity analysis using various scenarios. The LINTUL-5 crop model implemented in the SIMPLACE modeling platform was applied during the period 2001-2016 to simulate maize yields across four provinces in South Africa using previously defined scenarios of sowing dates. As expected, the selected methodology and the selectneralized among crop models with different levels of complexity and across distinct field crops.
  There has been limited data regarding the usefulness of lung ultrasound (US) in children with COVID-19.
 
  To describe lung US imaging findings and aeration score of 34 children with COVID-19.
 
  This study included 0-16-year-old patients with confirmed COVID-19, who were admitted between April 19 and June 18, 2020 in two hospitals in the city of Sao Paulo, Brazil. Lung US was performed as part of the routine evaluation by a skilled Pediatric Emergency physician. Clinical and laboratory data were collected and severity classifications were done according to an available clinical definition. The lung US findings were described for each lung field and a validated ultrasound lung aeration score was calculated. Data obtained was correlated with clinical information and other imaging modalities available for each case.
 
  Thirty-four confirmed COVID-19 patients had a lung US performed during this period. Eighteen (18/34) had abnormalities on the lung US, but eight of them (8/18) had a normal chest radiograph. Ultrasound lung aeration score medians for severe/critical, moderate, and mild disease were 17.5 (2-30), 4 (range 0-14), 0 (range 0-15), respectively (p = 0.001). Twelve patients (12/34) also had a chest computed tomography (CT) performed; both the findings and topography of lung compromise on the CT were consistent with the information obtained by lung US.
 
  Point-of-care lung US may have a key role in assessing lung injury in children with COVID-19.
 Point-of-care lung US may have a key role in assessing lung injury in children with COVID-19.
  Relatively little is known about which psychological treatment adjuncts might be helpful for supporting people with the most severe and complex forms of anorexia nervosa (AN) with very low weight and malnutrition requiring inpatient admissions, but targeting key perpetuating factors such as social emotional difficulties may be one way to advance knowledge. This pilot feasibility project reports on the development of an adolescent adaptation of Cognitive Remediation and Emotion Skills Training (CREST-A) and explores its acceptability, feasibility and possible benefits.
 
  An uncontrolled, repeated measures design was employed with data collected at the start and end of treatment. CREST‑A was investigated in two formats a10-session individual format delivered to acase series of 12patients and a5-session group format delivered to 3groups of 9patients.
 
  Acceptability, measured using aPatient Satisfaction Scale was 7/10 for the individual and 6/10 for the group format. Individual take-up was 100% and group take-up was 34.62%. Drop-out was 8.33% and 29.63% in the individual and group formats respectively. Homework was completed 66.67% and 75% of the time in the individual and group formats respectively. Patients reported medium-sized improvements in components of social emotional functioning measured using the Work and Social Adjustment Scale, the Toronto Alexithymia Scale and the Revised Social Anhedonia Scale in the individual and group formats.
 
  Future studies employing randomized controlled designs may now be warranted to advance this evidence base of this low intensity treatment adjunct.
 Future studies employing randomized controlled designs may now be warranted to advance this evidence base of this low intensity treatment adjunct.The gut microbiota is profoundly involved in glucose and lipid metabolism, in part by regulating bile acid (BA) metabolism and affecting multiple BA-receptor signaling pathways. BAs are synthesized in the liver by multi-step reactions catalyzed via two distinct routes, the classical pathway (producing the 12α-hydroxylated primary BA, cholic acid), and the alternative pathway (producing the non-12α-hydroxylated primary BA, chenodeoxycholic acid). BA synthesis and excretion is a major pathway of cholesterol and lipid catabolism, and thus, is implicated in a variety of metabolic diseases including obesity, insulin resistance, and nonalcoholic fatty liver disease. Additionally, both oxysterols and BAs function as signaling molecules that activate multiple nuclear and membrane receptor-mediated signaling pathways in various tissues, regulating glucose, lipid homeostasis, inflammation, and energy expenditure. Modulating BA synthesis and composition to regulate BA signaling is an interesting and novel direction for developing therapies for metabolic disease.  https://www.selleckchem.com/Bcl-2.html  In this review, we summarize the most recent findings on the role of BA synthetic pathways, with a focus on the role of the alternative pathway, which has been under-investigated, in treating hyperglycemia and fatty liver disease. We also discuss future perspectives to develop promising pharmacological strategies targeting the alternative BA synthetic pathway for the treatment of metabolic diseases.