This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Psychological well-being may play an important role in health behavior adherence and cardiovascular health, but there has been limited study of well-being in patients with heart failure. In this descriptive qualitative research study, we interviewed thirty patients with heart failure to explore their psychological experiences with heart failure and the perceived associations between positive psychological constructs and adherence to physical activity, diet, and medication recommendations. Interviews were transcribed, then coded in NVivo using directed and conventional content analysis, and the Consolidated Criteria for Reporting Qualitative Research checklist was applied to report our findings. Participants spontaneously reported positive psychological constructs both during an acute phase of illness and three months later. Participants most commonly experienced gratitude, acceptance, connectedness, and faith in the setting of heart failure. In contrast, pride, determination, and hope were identified most frequently as playing a role in health behavior adherence. Finally, participants reported a reinforcing relationship between positive constructs and health behavior engagement. These findings suggest that interventions to boost positive constructs have the potential to improve well-being and health behavior adherence in patients with heart failure. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.PURPOSE To compare in vitro fracture load, surface wear, and roughness after thermal cycling and cyclic mechanical fatigue loading among cemented microhybrid resin-based composite and ceramic occlusal veneers fabricated at two thicknesses (1.5 and 2.5 mm). MATERIALS AND METHODS Sixty-four extracted premolars without root canal treatment were prepared and restored with occlusal veneers of two thicknesses (1.5 and 2.5 mm), using four different materials microhybrid composite (MC), fiber-reinforced microhybrid composite (FMC), heat-pressed lithium disilicate ceramic (HPC), and computer-aided design/computer-aided manufactured lithium disilicate ceramic (CCC). The specimens underwent thermocycling and cyclic mechanical fatigue loading, and were then subjected to fracture testing, with loads at failure recorded as fracture load. Wear and surface roughness were recorded before and after fatigue loading. Results were analyzed using one-way ANOVA, two-way ANOVA (α = 0.05). RESULTS All specimens survived thermal cycling and cyclic mechanical fatigue loading. At 1.5-mm thickness, the mean fracture load of FMC was highest (3926.48 ± 556.54 N), while that of CCC was highest (3066.45 ± 559.94 N) at 2.5 mm. Regardless of thickness, the fracture load of CCC was higher than that of HPC (P = 0.004 and P = 0.023). The wear of MC and FMC was significantly higher than those of HPC and CCC (P≤0.001), but was similar in terms of the wear rate of tooth enamel. HPC exhibited the lowest surface roughness after fatigue loading (P≤0.001). CONCLUSION All tested occlusal veneers exhibited a fracture load considerably exceeding the maximum occlusal force in the posterior dentition. When the attainable space for restoration varies, different occlusal veneer materials should be considered. The surface wear and roughness also need to be considered when selecting materials. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Novel BODIPY photosensitizers were developed for imaging-guided photodynamic therapy. The introduction of a strong electron donor to the BODIPY core via a phenyl linker combined with the twisted arrangement between the donor and the BODIPY acceptor is essential for reducing the energy gap between the lowest singlet excited state and the lowest triplet state (∆ E ST ), leading to a significant enhancement in the intersystem crossing (ISC) of the BODIPYs. Remarkably, the BDP-5 with the smallest ∆ E ST (≈0.44 eV) exhibited excellent singlet oxygen generation capabilities in both organic and aqueous solutions. BDP-5 also displayed bright emission in the far-red/near-infrared region in the condensed states. More importantly, both in vitro and in vivo studies demonstrated that BDP-5 NPs displayed a high potential for photodynamic cancer therapy and bioimaging. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.In analogy to covalent reactions, the understanding of noncovalent association pathways is fundamental to influence and control any supramolecular process. Following an approach that is reminiscent of covalent methodologies, we study here, for the first time, the mechanism of G-quadruplex formation in organic solvents. Our results support a reaction pathway in which the cation shifts first the equilibrium towards a G-quartet transient intermediate, which then acts as a template in the formation of the G-quadruplex product. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.The periodic twist behaviors of amyloid fibrils initiated and formed on block copolymer films with nanoscale features are studied. The discovery of twist variations even in a single amyloid fibril is reported the fibril can vary its twist extents in response to the underlying nanopatterned surfaces by keeping its neighboring crossover sections right above the periodic nanodomains and tuning the distance between neighboring crossover sections based on either the periodic nanodomain distance or the fibril contour direction. This nanopattern-induced twist polymorphism arises from the fibril's two edges, exhibiting different hydrophobic interactions with the periodic nanodomains, as demonstrated by simulation studies. This work contributes to the understanding of surface effects on twist polymorphism in amyloid fibril structures that may be important to fibril polymorphism in amyloid pathologies and bioapplications of amyloid fibrils. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Poly(phenylacetylene)s is a family of helical polymers constituted by conjugated double bonds that are fixed into specific helical structures due to supramolecular and/or steric interactions among pendant groups. Raman spectra of these polymers show a structural fingerprint of the polyene backbone which, in combination with its helical orientation, makes them great candidates to study their helical structure by Raman Optical Activity (ROA). Four different well-known poly(phenylacetylene)s adopting different scaffolds and ten different helical senses have been prepared.  https://www.selleckchem.com/products/wnt-c59-c59.html  For all of these, Raman and ROA spectra were recorded which allows us to establish ROA spectrum/helical sense relationships a right-handed orientation of the polyene backbone (P helix ) produces a triplet of negative ROA bands, whereas a M helix produces a positive triplet ROA pattern.  Raman and ROA spectra of each polymer exhibited the same profile and the sign of the ROA spectrum was opposite to the lowest energy ECD band, thus indicating a resonance effect.