CONCLUSIONS Compared to Han juveniles, She juveniles present an orthognathous and long face with vertical growth pattern. Sex differences are not apparent in juveniles of both She and Han nationality.PURPOSE To investigate the effects of basic periodontal treatment on the levels of endothelin (ET), vascular endothelial growth factor-A (VEGF-A) and tumor necrosis factor-α (TNF-α) in gingival crevicular fluid and serum. METHODS A total of 57 patients with periodontitis (experimental group) and 43 healthy examinees (control group) admitted to Shenzhen Hospital of Guangzhou University of Chinese Medicine from October to May 2018 were selected. Patients received subgingival scaling and root planing for 6 weeks. Then various indexes were compared, including bleeding on probing (BOP), plaque index (PI), probe depth (PD), clinical attachment level (CAL) and gingival index (GI), as well as the levels of ET, VEGF-A and TNF-α in gingival crevicular fluid and serum. The correlation between ET, VEGF-A and TNF-α was analyzed. The data were analyzed with SPSS 21.0 software package. RESULTS Periodontal indexes including BOP, PI, PD, CAL and GI in the experimental group were significantly increased after treatment (P0.05), while was positively correlated with VEGF-A levels (P less then 0.05). CONCLUSIONS Basic periodontal treatment can reduce the levels of ET, VEGF-A and TNF-α in gingival crevicular fluid and serum of patients with periodontitis, and improve the periodontal status; moreover, ET level in gingival crevicular fluid is positively correlated with TNF-α level.PURPOSE To investigate the expression of rapamycin target protein (mTOR) mRNA and transferrin receptor 1(Tfr1) mRNA in mucoepidermoid carcinoma of parotid gland and its relationship with prognosis. METHODS From June 2013 to July 2015 in Tangshan Workers' Hospital, 35 patients with mucoepidermoid carcinoma of parotid gland were selected. The relative expression of mTOR and Tfr1 mRNA in mucoepidermoid carcinoma of parotid gland was detected. The relationship between mTOR mRNA, Tfr1 mRNA and the clinicopathology and prognosis of mucoepidermoid carcinoma of parotid gland was analyzed using SPSS19.0 software package. RESULTS The relative expression levels of mTOR mRNA and Tfr1 mRNA in mucoepidermoid carcinoma of parotid gland were significantly higher than those in adjacent tissues(P less then 0.05). The relative expression of mTOR mRNA and Tfr1 mRNA was correlated with invasion depth, tumor grade, TNM stage and cervical lymphatic metastasis(P less then 0.05). The relative expressions of mTOR and Tfr1 in patients with good prognosis were significantly lower than those in patients with poor prognosis (P less then 0.05). The AUC of mTOR mRNA was 0.815, higher than that of Tfr1 mRNA(0.813). The AUC of mTOR mRNA combined with Tfr1 mRNA was 0.922, higher than that of mTOR mRNA and Tfr1 mRNA alone. Cox univariate and multivariate analysis showed that differentiation, TNM stage, mTOR mRNA and Tfr1 mRNA were closely related to poor prognosis of mucoepidermoid carcinoma of parotid gland. CONCLUSIONS The relative expression of mTOR mRNA and Tfr1 mRNA in patients with mucoepidermoid carcinoma of parotid gland was significantly increased, which can be used to evaluate the prognosis of patients.PURPOSE Using impact test to study energy absorption ability of mouthguard splints of different thickness and materials. METHODS In this experiment, group 1 was BIOPLAST 5 mm splint, group 2 was BIOPLAST 4 mm splint, group 3 was BIOPLAST 3 mm splint，group 4 was BIOPLAST 2 mm splint and group 7 was BIOPLAST 1 mm splint. Group 5 was ERKOLOC-PRO 2 mm splint, group 6 was DURAN 2 mm splint. Mouthguard splints were clashed by impact head from different heights. Digital Image Correlation System was used to record the process of the test. Images were transferred to data processing software, to analyze incident speed, incident depth and rebound height of the impact head. Absorbed energy and energy absorption ratio were calculated to analyze energy absorption ability of mouthguard splints of different thickness and materials. The data were analyzed using SPSS 22.0 software package for one-way analysis of variance and LSD. RESULTS The higher impact head fell, the larger energy absorption ratio was. There was significant difference among group 1, 2, 3, 4, 7 in average energy absorption ratio（P less then 0.05）, and group 7 was the largest. There was significant difference among group 4, 5, 6 in average energy absorption ratio（P less then 0.05）, among which group 4 and group 5 were larger. CONCLUSIONS 3 mm splint is good enough to be used to make mouthguard, which is also thinner and more comfortable. Splint of soft material is more suitable for mouthguard than splint of hard material.PURPOSE Bisphosphonates are commonly used to treat bone-derived malignant tumors currently. In recent years, with the widespread use of these drugs, reports on the difficulty of wound healing (DWH) increase remarkably. However, the mechanism is still unclear. The soft tissue injury was suspected to cause DWH in many recent reports. This experiment was designed to explore the influence of zoledronic acid on fibroblast, and investigate the possible mechanisms leading to DWH. METHODS NIH 3T3 fibroblasts were routinely cultured in vitro. The influence of zoledronic acid on apoptosis, proliferation and migration of fibroblast were tested with flow cytometry, MTT and cell migration assay, respectively. The results of each experimental group were compared with the control group using SPSS 17.0 software package. RESULTS At a concentration of 5-50 μmol/L, zoledronic acid could dose-dependently inhibit the activity of fibroblast proliferation and migration, and up-regulate apoptosis with significant difference (P less then 0.05). CONCLUSIONS Zoledronic acid can up-regulate cell apoptosis, inhibit proliferation and migration of fibroblast, suggesting that soft tissue impairment might contribute to the occurrence of DWH.PURPOSE Using impact test to study energy absorption ability of mouthguard splints of different thickness and materials. METHODS In this experiment, group 1 was BIOPLAST 5 mm splint, group 2 was BIOPLAST 4 mm splint, group 3 was BIOPLAST 3 mm splint，group 4 was BIOPLAST 2 mm splint and group 7 was BIOPLAST 1 mm splint. Group 5 was ERKOLOC-PRO 2 mm splint, group 6 was DURAN 2 mm splint. Mouthguard splints were clashed by impact head from different heights. Digital Image Correlation System was used to record the process of the test. Images were transferred to data processing software, to analyze incident speed, incident depth and rebound height of the impact head. Absorbed energy and energy absorption ratio were calculated to analyze energy absorption ability of mouthguard splints of different thickness and materials. The data were analyzed using SPSS 22.0 software package for one-way analysis of variance and LSD.  https://www.selleckchem.com/products/tat-beclin-1-tat-becn1.html  RESULTS The higher impact head fell, the larger energy absorption ratio was. There was significant difference among group 1, 2, 3, 4, 7 in average energy absorption ratio（P less then 0.