https://www.selleckchem.com/products/tetrazolium-red.html Cardiovascular disease is a leading cause of morbidity and mortality in the United States. Dietary supplements, such as those rich in antioxidants, have the potential to improve markers of cardiovascular health, but little is known about the total effect of these supplements. The purpose of this analysis is to identify the effect size of supplementation with aronia berry extracts and to evaluate how age may influence these effects. This analysis included a literature review of controlled trials evaluating the effects of daily aronia berry supplementation for an average of 6-8 weeks on the outcomes of total cholesterol and blood pressure. Three distinct analyses were conducted systolic blood pressure, diastolic blood pressure, and total cholesterol. The moderator of age was evaluated for each of the three outcome measures. Daily supplementation with aronia berry extracts for 6-8 weeks significantly reduces systolic blood pressure, which is a key risk factor for cardiovascular disease, as well as total cholesterol. These effects are most significant in adults over the age of 50 years. Supplementation with aronia berry is a safe and effective way to reduce total cholesterol and systolic blood pressure, with even larger effects among adults over the age of 50 years. Daily supplementation with aronia berry extracts for 6-8 weeks significantly reduces systolic blood pressure, which is a key risk factor for cardiovascular disease, as well as total cholesterol. These effects are most significant in adults over the age of 50 years. Supplementation with aronia berry is a safe and effective way to reduce total cholesterol and systolic blood pressure, with even larger effects among adults over the age of 50 years.Intrathecal (IT) dosing (ie, injection into the subarachnoidal space at the lumbar region) is a common route of administration in cynomolgus monkey preclinical safety studies conducted for antisense oligonucleot