https://www.selleckchem.com/products/xl092.html Plasmonic nanocavities enable the confinement of molecules and electromagnetic fields within nanometric volumes. As a consequence, the molecules experience a remarkably strong interaction with the electromagnetic field to such an extent that the quantum states of the system become hybrids between light and matter polaritons. Here, we present a nonperturbative method to simulate the emerging properties of such polaritons it combines a high-level quantum chemical description of the molecule with a quantized description of the localized surface plasmons in the nanocavity. We apply the method to molecules of realistic complexity in a typical plasmonic nanocavity, featuring also a subnanometric asperity (picocavity). Our results disclose the effects of the mutual polarization and correlation of plasmons and molecular excitations, disregarded so far. They also quantify to what extent the molecular charge density can be manipulated by nanocavities and stand as benchmarks to guide the development of methods for molecular polaritonics.Metal oxidation initiates from surface adsorption to subsurface and bulk reaction through continuous interfacial phase transformation from metals to oxides. How the initial interfacial process affects the whole process of metal oxidation remains largely elusive because of the lack of direct observation of the evolving interface. Here, through in situ atomic-scale environmental TEM observations of Cu surface reaction in water vapor, we demonstrate that the interfacial strain between the substrate and growing oxide is coupled into the continuing chemical reaction that determines the reaction kinetics. Atomic imaging of the reaction process in real time reveals that the growing oxides could temporarily possess a disordered CuOx phase to lower its interfacial strain with Cu substrate and can transform to a crystalline Cu2O phase later. This flexibility of the oxide phase results from the strong chemom