rs, comparable obstetric and gynecological outcomes were seen, with residency and parity being independently associated with higher pregnancy rate.
 Although resident women in OB/GYN reported on more adverse lifestyle parameters, comparable obstetric and gynecological outcomes were seen, with residency and parity being independently associated with higher pregnancy rate.
  Pre-eclampsia is associated with an increased risk of future cardiovascular disease. Maladaptive placentation or malperfusion, as well as predisposing cardiovascular or metabolic risk for endothelial dysfunction, contribute to the systemic inflammatory response that establishes the origins of the disease. The purpose of this study was to investigate the relationship between placental size and cardiovascular risk when assessed at six months postpartum in women who experienced pre-eclampsia.
 
  Maternal clinical and biochemical cardiovascular risk factors were used to categorize preeclamptic women into high vs. low lifetime cardiovascular disease risk profiles at six months postpartum. A multivariable logistic regression model was then used to identify the association between placental weight to birth weight ratio and high lifetime cardiovascular disease risk, adjusting for maternal age, pre-pregnancy BMI, and severity of pre-eclampsia. A p-value of < 0.05 was deemed statistically significant.
 
  186/216 womtum cardiovascular risk screening and intervention.
  Evaluation of the external genitalia is an important part of prenatal ultrasound.  https://www.selleckchem.com/products/pexidartinib-plx3397.html  However, there is no standardized methodology that includes biometric measurements and normative data to be able to carry out this evaluation.
 
  To develop a standardized methodology for fetal genital biometry and obtain reference values for use in mid-trimester ultrasound.
 
  A prospective cross-sectional study was used. 273 male and 253 female fetuses of normal, singleton pregnancies at 18 to 22 weeks were included. Measurements of fetal penis length, penile width and transverse scrotal diameter in male fetuses and bilabial diameter in female fetuses were performed by transabdominal ultrasound. Reference values were calculated for each gestational week.
 
  Realization of the open-legs axial plane is described as a working methodology. Normative data for penile length, penile width, transverse scrotal diameter and bilabial diameter are defined, including mean, minimum and maximum values, range, and 5th, 10th, 90th and 95th percentiles.
 
  We have provided a standardized methodology using the open-legs axial plane, which would integrate the main measurements. In addition with the normative data constructed from their use, we hope to be able to improve the external genitalia assessment and diagnosis of genital anomalies in mid-trimester ultrasound.
 We have provided a standardized methodology using the open-legs axial plane, which would integrate the main measurements. In addition with the normative data constructed from their use, we hope to be able to improve the external genitalia assessment and diagnosis of genital anomalies in mid-trimester ultrasound.
  The maternal bone structure is the largest calcium reserve for the fetus during pregnancy, and this is claimed to lead to a bone mineral density (BMD) reduction in pregnant women. The primary outcome of the present work was to assess the BMD in a group of healthy pregnant women.
 
  In this prospective case - control observational study, a non-consecutive group of pregnant women with uncomplicated pregnancy at or >37 weeks were enrolled at the unit of Obstetrics and Gynecology, University of Parma, from February to December 2020. The study subjects were submitted to a sonographic examination of the proximal femur with Radiofrequency Echographic Multi Spectrometry (REMS) technology to quantify the BMD of the femur. The BMD values obtained in the study group were compared with those of a control group of non-pregnant women matched for age, ethnicity and pre-pregnant body mass index (BMI).
 
  Overall, 78 pregnant women at 39.1 ± 1.5 weeks were assessed. Compared with non-pregnant women, the femoral BMD values egnancy.Sight distance is an important indicator of vehicle safety at intersections. Traditional intersection design methods might be not suitable for the autonomous vehicle (AV) because its perception differs from that of the human driver, on which AASHTO Greenbook 2018 are based. Since, to guarantee future operational safety, intersection design needs to consider the impact of the AV, this study investigates and quantifies the relationships between intersection angle on skewed intersections. The operational design domain (ODD) is defined as the required detecting angle and distance within the skewed intersection's speed range. Calculations for acute-side detecting angle, obtuse-side detecting angle, and obtuse-side detecting distance formulae were developed based on sine theorem and inverse trigonometric function; leg length of the sight triangle along an intersection's major road was calculated by multiplying the design speed by the time gap. Calculation results show that the current design criteria cannot provide sufficient sight distance for the AV if the approach speed is not controlled. The AV's higher approach speed, even when controlled, can improve both intersection safety and efficiency. The ODD requires different detecting angles and distances for the intersection angles of 55, 60, 65, 70, 75, 80 degrees. Intersection angle was found to have greater influence on the detecting angle when the road design speed was higher than 40 km/h, and the obtuse-side detecting distance increased rapidly when speed on the major road reached 50 km/h. For AV safety performance, engineers should incorporate the AV's detecting angle, distance, and time gap into the skewed intersection design criteria. AVs technology needs to comply with the ODD defined by the intersection geometrics.
  Familial hypercholesterolaemia (FH) is an autosomal disorder of lipid metabolism presenting with increased cardiovascular risk. LDLR mutations are the cause of disease in 90% of the cases but functional studies have only been performed for about 15% of all LDLR variants. In the Portuguese Familial Hypercholesterolemia Study (PFHS), 142 unique LDLR alterations were identified and 44 (30%) lack functional characterization. The aim of the present work is to increase evidence for variant classification by performing functional characterization of 13 LDLR missense alterations found in Portugal and in 20 other countries.
 
  Different LDLR mutants were generated by site-directed mutagenesis and expressed in CHO-ldlA7 cells lacking endogenous expression of LDLR. To determine the effects of alterations on LDLR function, cell surface expression, binding and uptake of FITC-LDL were assessed by flow cytometry and Western blot.
 
  Of the 13 variants studied 7 were shown to affect LDLR function - expression, binding or uptake, with rates lower than 60% p.