https://www.selleckchem.com/products/apg-2449.html Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Cancer stem cells (CSCs), also known as tumor-initiating cells, are a subpopulation of tumor cells found in many human cancers that are endowed with self-renewal and pluripotency. CSCs may be more resistant to conventional anticancer therapies than average cancer cells, as they can easily escape the cytotoxic effects of standard chemotherapy, thereby resulting in tumor relapse. Despite significant progresses in related research, effective elimination of CSCs remains an unmet clinical need. CSCs are localized in a specialized microenvironment termed the niche, which plays a pivotal role in cancer multidrug resistance. The niche components of CSCs, such as the extracellular matrix, also physically shelter CSCs from therapeutic agents. Colorectal cancer is the most common malignancy worldwide and presents a relatively clear process of cancer initiation and development, making it an ideal model for CSC niche research. Here, we review recent advances in the field of CSCs using colorectal cancer as an example to illustrate the potential therapeutic value of targeting the CSC niche. These findings not only provide a novel theoretical basis for in-depth discussions on tumor occurrence, development, and prognosis evaluation, but also provide new strategies for the targeted treatment of cancer. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND Inflammation is a complex process arises due to the host defense system against different internal and external stimuli. It is believed that persistent inflammation may lead to chronic inflammatory diseases such as inflammatory bowel disease, neurological and cardiovascular diseases. These are health threatening problems world widely accepted and emerged due to the existence of inflammatory response which may turn into deleterious effec