https://www.selleckchem.com/products/pt2385.html © The Author(s) 2020. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.BACKGROUND Increased pericardial adipose tissue is associated with higher risk of cardiovascular disease. We aimed to determine if HIV status was independently associated with larger pericardial adipose tissue volume and to explore possible HIV-specific risk factors. METHODS Persons with HIV (PWH) were recruited from the Copenhagen Comorbidity in HIV Infection (COCOMO) Study and matched 11 on age and *** to uninfected controls. Pericardial adipose tissue volume was measured using cardiac CT. RESULTS A total of 587 PWH and 587 controls were included. Median age was 52 years, 88% were male. HIV status was independently associated with 17 mL (95% confidence interval [10, 23]), p less then .001 larger pericardial adipose tissue volume. Larger pericardial adipose tissue volume was associated with low CD4+ nadir and prior use of stavudine, didanosine and indinavir. Among PWH without thymidine analogue or didanosine exposure, time since initiating cART (per 5-year use) was associated with l6 mL [-6, -25] lower pericardial adipose tissue volume, p=.002. CONCLUSION HIV status was independently associated with larger pericardial adipose tissue volume. Severe immunodeficiency, stavudine, didanosine and indinavir were associated with larger pericardial adipose tissue volume. PWH with prior exposure to these drugs may constitute a distinct cardiovascular risk population. © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.Pikas are widely distributed in the Northern Hemisphere and are highly adapted to cold and alpine environments. They are one of the most complex and problematic groups in mammalian systematics, and t