https://www.selleckchem.com/products/sbe-b-cd.html that ALT could be used as the main indicator for clinical prediction of poor prognosis for PNAC. ALT is an independent risk factor of poor prognosis in children with PNAC. ALT is an independent risk factor of poor prognosis in children with PNAC. To observe the effect of early mechanical ventilation on the expression of inflammatory factors and prognosis of patients with severe traumatic brain injury (sTBI). From January 2017 to December 2020, 138 patients with sTBI admitted to the department of the emergency of Xinhua Hospital Chongming Branch were enrolled. Although some patients were admitted to hospital without acute respiratory failure, their Glasgow coma score (GCS) were less than 8, they bad risk of hypoxia, so early mechanical ventilation was required. According to the patient's condition and the willingness of family members, patients were divided into mechanical ventilation group (tracheal intubation mechanical ventilation) and conventional oxygen inhalation group (nasal catheter or mask oxygen inhalation) in the end. The arterial partial pressure of oxygen (PaO ), arterial partial pressure of carbon dioxide (PaCO ), oxygenation index (PaO /FiO ), tumor necrosis factor-α (TNF-α), and interleukin (IL-6, IL-10) levels at admission, preional oxygen inhalation group before operation. Compared with the conventional oxygen inhalation group, the GCS score (11.7±3.1 vs. 9.1±4.6) and the proportion of successful weaning [62.5% (45/72) vs. 44.0% (29/66)] were significantly higher, and the duration of successful weaning (hours 63.5±28.6 vs. 88.1±33.9) was significantly shorter in the mechanical ventilation group 1 week after operation. Early mechanical ventilation in sTBI patients can significantly improve oxygen supply, inhibit the release of pro-inflammatory factors, reduce secondary brain damage, and effectively improve the prognosis. Early mechanical ventilation in sTBI patients can significantly improve oxygen s