https://www.selleckchem.com/products/harmine.html Genome-scale studies focusing on molecular profiling of cancers across tissue types have revealed a plethora of aberrations across the genomic, transcriptomic, and epigenomic scales. The significant molecular heterogeneity across individual tumors even within the same tissue context complicates decoding the key etiologic mechanisms of this disease. Furthermore, it is increasingly likely that biologic mechanisms underlying the pathobiology of cancer involve multiple molecular entities interacting across functional scales. This has motivated the development of computational approaches that integrate molecular measurements with prior biological knowledge in increasingly intricate ways to enable the discovery of driver genomic aberrations across cancers. Here, we review diverse methodological approaches that have powered significant advances in our understanding of the genomic underpinnings of cancer at the cohort and at the individual tumor scales. We outline the key advances and challenges in the computational discovery of cancer mechanisms while motivating the development of systems biology approaches to comprehensively decode the biologic drivers of this complex disease.The absence or hypoplasia of the carpal scaphoid bone is rare and unfrequent, especially if isolated, as it is usually associated with other congenital disorders. Such anomaly is usually the result of fetal development alterations before week 11 of pregnancy. We introduce the case of a 53-year-old woman with chronic wrist pain and persistent pain after surgical intervention of the carpal tunnel syndrome in the left hand. X-rays and CT confirmed the patient's hypoplasia of the scaphoid bone with carpal instability diagnosis. The patient became asymptomatic after surgical intervention and post-surgical rehabilitation. Oncogenic gene transcripts in advanced lung cancer are a strong indication for targeted therapy. Cytology specimens are often the only ma