https://www.selleckchem.com/CDK.html Furthermore, XIST could affect cell growth of OGD-induced neuronal cells. Further analysis showed that XIST could regulate TIPARP by binding to miR-455-3p, and overexpression of miR-455-3p or inhibition of TIPARP could reverse the effects of high XIST expression on OGD-induced neuronal cells. On the contrary, suppression of miR-455-3p or promotion of TIPARP could reverse the effects of low XIST expression on OGD-induced neuronal cells. XIST could affect cell proliferation and apoptosis through miR-455-3p/TIPARP axis in OGD-induced neuronal cells, providing a new regulatory network to understand the pathogenesis of hypoxia-induced neuronal injury.A new type of multifunctional bis(salamo)-based fluorogenic sensor H2BS was designed and synthesized. Under the action of VDMF VH2O = 9 1, the fluorogenic sensor can identify Cu2+ and B4O72-, in which N and O atoms can serve as binding sites for Cu2+ and B4O72-, the stoichiometry of the binding of the fluorogenic sensor H2BS and Cu2+ has been confirmed by titration experiment, working curve, ESI-MS analysis and DFT calculation. The pH response experiment also confirmed that the fluorogenic sensor can recognize Cu2+ and B4O72- in the pH range applicable to the physiological environment. The minimum detection limit of H2BS for Cu2+ and B4O72- recognition reaches 1.12 × 10-7 and 5.56 × 10-8 M, and the fluorogenic sensor H2BS has been successfully applied to Cu2+ detection in actual water samples, and the test strip for detecting Cu2+ and B4O72- was obtained. Meanwhile, the success of the test strip experiment made the fluorogenic sensor H2BS to recognize Cu2+ and B4O72- widely used in daily life. A new type of salamo-based multifunctional fluorogenic sensor H2BS was designed and synthesized to identify Cu2+ and B4O72- in aqueous solvent systems. Added Cu2+ to H2BS can cause fluorescence quenching. Further experiments showed that H2BS and Cu2+ form a stable 12 complex, while B4O72- can also c