Infraorbital dark circles are a common esthetic concern which can be challenging to treat given their multifactorial nature. Under-eye darkcircles are seen in all skin types, with a strong familial component in darker skin types. Other major contributing factors include soft tissue and bony changes, skin changes, lifestyle contributions, and allergies. Involutional periorbital volumetric changes cause volume loss in the tear trough, naso-jugal and palpebro-malar grove, skin and subcutaneous tissues with tethering of the eyelid skin to the tear trough ligament, giving a sunken and hollow appearance to the lower lid. Associated prolapse of the orbital fat and thin skin can worsen the appearance of a dark circle. Hyaluronic acid fillers placed in the pre-periosteal plane in the tear trough, palpebro-malar and naso-jugal grooves, give good results in patients with thick eyelid skin and negligible fat prolapse. However, in patients with thin skin and moderate fat prolapse, authors have reported worsening outcomes with risk of Tyndall (blue-gray discoloration) and contour irregularities from visible lumps.
 
  To describe a novel technique to improve dark circles caused by a diffuse valley-type pre-septal tear trough deformity in patients with thin eyelid skin.
 
  Retrospective case note review of 330 eyelids treated with microdroplet subdermal placement of filler in the preseptal tear trough area by a single surgeon.
 
  This novel technique shows good esthetic outcomes in patients with dark circles, with good longevity and a low risk of complications.
 This novel technique shows good esthetic outcomes in patients with dark circles, with good longevity and a low risk of complications.
  To investigate associations between changes in vegetable and fruit (V&F) intakes and anthropometric indices (weight, BMI, % body fat, waist circumference), including differences by sex, during a dietary weight-loss intervention.
 
  Adults (18-45 years) with overweight/obesity (BMI 25-35 kg/m
  ) entered a 10-week pre-post study, receiving individualised consults with an Accredited Practising Dietitian targeting increased V&F intakes. Dietary intake was assessed using 24-hour recalls and food frequency questionnaires. Linear mixed models were used to examine how much of the changes in anthropometric indices were explained by changes in V&F intakes. Sex differences were assessed by Wilcoxon rank sum tests.
 
  Of the 43 participants enrolled, 34 completed the study (53% female).  https://www.selleckchem.com/products/geneticin-g418-sulfate.html  Significant differences in energy intake and anthropometric indices were observed between males and females at baseline. After 10 weeks, females significantly reduced their weight (-2.9%, P < .01), BMI (-0.82 kg/m
  , P < .01), waist circumference (-1.70 cm, P < .01), energy intake (-824 kJ/day, P = .01) and improved diet quality (-14.0% energy-dense, nutrient-poor foods, P < .01). Males significantly reduced weight (-2.5%, P = .04), BMI (-0.76 kg/m
  , P = .03), waist circumference (-2.40 cm, P = .02), energy intake (-2875 kJ/day, P < .01), increased fruit intake (+0.89 serves/day, P = .02) and improved diet quality (-6% energy-dense, nutrient-poor foods, P < .01). Compared to the other sex, greater reductions were observed in energy intake in males and energy-dense, nutrient-poor foods in females. Linear mixed models identified that changes in V&F intakes did not explain the variation in anthropometric measures.
 
  Future interventions may benefit from trialling sex tailored messages to enhance effects on anthropometric changes.
 Future interventions may benefit from trialling sex tailored messages to enhance effects on anthropometric changes.Molecular characterization of cancers is important in dictating prognostic factors and directing therapy. Next-generation sequencing of plasma circulating tumor DNA (ctDNA) offers less invasive, more convenient collection, and a more real-time representation of a tumor and its molecular heterogeneity than tissue. However, little is known about the clinical implications of ctDNA assessment in gynecologic cancer. We describe the molecular landscape identified on ctDNA, ctDNA concordance with tissue-based analysis, and factors associated with overall survival (OS) in gynecologic cancer patients with ctDNA analysis. We reviewed clinicopathologic and genomic information for 105 consecutive gynecologic cancer patients with ctDNA analysis, including 78 with tissue-based sequencing, enrolled in the Profile-Related Evidence Determining Individualized Cancer Therapy (NCT02478931) trial at the University of California San Diego Moores Cancer Center starting July 2014. Tumors included ovarian (47.6%), uterine (35.2%), cetors. This study provides evidence for the utility of ctDNA in determining outcome and individualizing cancer therapy in patients with gynecologic cancer.
  To examine the role of frailty in risk of re-hospitalisation and mortality for aged care residents following a fall injury hospitalisation.
 
  Retrospective analysis of linked hospitalisation and aged care data of adults aged ≥65years residing in aged care. A semi-competing risk analysis examined risk of hospital readmission.
 
  Residents who had intermediate or high frailty, who were aged 70-79 or 80-89years, who had 1-2 or ≥3 comorbidities, sustained a hip fracture, and who had either low, moderate or high complex health-care requirements had a higher risk of being readmitted to hospital. Frailty was not associated with mortality for those with no hospital readmission or mortality after readmission.
 
  Frailty is an important prognostic factor associated with readmission for residents of aged care hospitalised for a fall injury. Frailty screening could assist to identify people at a high risk of re-hospitalisation following a fall injury.
 Frailty is an important prognostic factor associated with readmission for residents of aged care hospitalised for a fall injury. Frailty screening could assist to identify people at a high risk of re-hospitalisation following a fall injury.Researchers who desire to make positive changes for vulnerable populations often conduct problem-focused studies. Although problem-focused research is important, when such studies are not carefully designed, their results can contribute to a deficit discourse. A deficit discourse is a narrative that describes the person through a myopic lens of negativity characterized only by illness, death, depression, failure, or the like. Deficit discourse negatively affects how health care providers and society interact with vulnerable people. This article discusses deficit discourse in health care and strengths-based research an ethical approach to working with vulnerable individuals in research settings and a strategy to overcome deficit discourse. Strengths-based research approaches balance risks with countermeasures that include areas that are positive and amenable to growth or intervention. Strengths-based research can be conducted using qualitative, quantitative, or mixed-methods methodology. Strengths-based research should be culturally relevant and population-specific, often including the individuals of study throughout the process.