https://www.selleckchem.com/products/MLN8237.html In the phantom the segmentation algorithm was found to improve the accuracy and precision of attenuation coefficient estimates by up to 80% and 90%, respectively. The effect of the algorithm was then measured invivo using 32 radiofrequency B-mode datasets from the breasts of two healthy female volunteers, producing a 5 to 25% reduction in mean attenuation coefficient estimates and a 30 to 50% reduction in standard deviation of attenuation coefficient across different positions within each breast. The results suggest that the segmentation algorithm may improve the accuracy and precision of attenuation coefficient estimates invivo.Features of an acoustic energy trapping and outflow in a High-overtone Bulk Acoustic Resonator (HBAR) were considered. On the example of a specified resonator based on a piezoelectric layered structure (PLS) as "Al/AlN/Mo/(100) diamond", the simulation of the propagation of microwave acoustic waves in the range of 10-6000 MHz by Finite Element Method (FEM) in COMSOL Multiphysics has been carried out. It was found that the magnitude of acoustic energy retained in the substrate under the bottom electrode depends substantially on the relation between the HBAR's antiresonance frequency fa,n and the cut-off frequencies fs,n-k and fs,n-k+1 of the substrate. The term "cut-off frequency" has the meaning of the frequency point when integer value of half-waves fits along the thickness of substrate. Parameter gk,n estimating the degree of the HBAR's energy trapping has been proposed. If 0.5 less then gk,n less then 1, then a retention of acoustic energy in the HBAR's center as a maximal ET-effect at the overtone frequency fa,n should be fulfilled. Increasing the width of the top electrode as well as the HBAR's aperture should expand the frequency interval in which the retained elastic energy in the vicinity of the HBAR's center will be greater than the similar outside. It was shown that the area-average