These results are encouraging as they show that outcomes from large randomized clinical trials can be reproduced in the everyday clinical setting. Neoadjuvant chemotherapy may be the treatment of choice for HR-negative and/or HER2-positive early breast cancer patients. This may also be the case for the majority of HR-positive and HER2-negative patients with either locally advanced disease or disease extending to the axillary lymph nodes, as it may result in more conservative surgical interventions with fewer post-operative complications.Purpose To investigate the expression of KI-67 and LEF-1 in patients after breast cancer resection and its effects on patients' prognosis. Methods A total of 89 breast cancer patients admitted to the first affiliated Hospital of Shantou University Medical College from January 2010 to February 2013 were enrolled as the study group, and 76 healthy individuals were enrolled as the control group. Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expression of KI-67 and LEF-1 in the serum.  https://www.selleckchem.com/products/glutathione.html  The relationship of the two indexes and clinicopathological data of the breast cancer patients were analyzed. In addition, the diagnostic value of KI-67 and LEF-1 in breast cancer patients was analyzed by receiver operating characteristic (ROC) curves, and their diagnostic value in the postoperative 5-year recurrence was also analyzed. Furthermore, the expression of KI-67 and LEF-1 in patients with postoperative recurrent breast cancer within 5 years was evaluated. Results The expression of KI-67 anertain diagnostic value in breast cancer. The expression of the two indexes is related to tumor size and lymph node metastasis, and the survival of patients with high expression of KI-67 and LEF-1 is worse.Purpose A number of studies have provided concrete evidence about the role of Long noncoding RNAs (LncRNAs) in the development and progression of cancer. As such LncRNAs are believed to exhibit the potential to be used as therapeutic targets for the treatment of cancer. This study was undertaken to investigate the role and therapeutic implication of LncRNA PCAT29 in triple-negative breast cancer. Methods The breast cancer cell lines MDA-MB-231, MDA-MB-436, BT20, HCC70 and HCC38 and non-cancer cell line MB157 were used in this study. Gene expression analysis was performed by qRT-PCR. Cell proliferation was monitored by MTT and colony formation assays. Apoptosis was detected by annexin V/propidium iodide (PI) assay. Cell migration and Invasion was detected by wound heal and transwell assays. Results The expression of LncRNA PCAT29 was significantly suppressed in the breast cancer tissues and the triple-negative breast cancer cell lines. PCAT29 overexpression caused inhibition of the proliferation rate and colony formation of the MDA-MB-231 cells. The proliferation of MD-MB-231 cells was inhibited by apoptotic cell death which was accompanied by elevation of Bax and depletion of Bcl-2 expression. The wound healing assay showed that PCAT29 caused remarkable inhibition of the MDA-MB-231 cell migration. The transwell assay showed that PCAT29 overexpression resulted in 65% inhibition of the MDA-MB-231 cell invasion. Conclusion PCAT29 regulates the proliferation, migration and invasion of breast cancer cells and may point to a novel therapeutic target in triple-negative breast cancer.During laryngeal carcinogenesis, a variety of genomic imbalances are involved in hyperplastic and dysplastic laryngeal epithelia as early or progressive genetic events, respectively. Oncogenes' overactivation is a crucial genetic event in malignant and pre-malignant neoplastic epithelia. Especially, deregulation of crucial pathways including transcription factors - such as c-Fos and c-Jun - leads to an aberrant expression of other crucial genes responsible for cell homeostasis. Upregulation of c-Fos and c-Jun proto-oncogenes -due to increased copy numbers (amplification) or intra-genic point mutations- seems to be correlated with aggressive biological behaviour in laryngeal squamous cell carcinomas (LSCCs). In the current special molecular article we explored the role of c-Fos/c-Jun complex deregulation in LSCC.Langerhans cell histiocytosis (LCH) is disease process characterized by clonal proliferation of CD1a+ dendritic cells within an inflammatory infiltrate of hematopoietic derived cells. LCH can manifest with a broad spectrum of symptoms and can involve single organs or have a multisystem distribution. Central nervous system (CNS) involvement of LCH can manifest as granulomatous parenchymal or pituitary mass lesions. Focal, space-occupying lesions, such as masses in the meninges, choroid plexus, and brain parenchyma may contain CD1a+ LCH cells, lymphocytes, and macrophages with histology similar to that of extracranial lesions. Here, we describe a rare case of multisystem LCH in an adult patient presenting with spinal lesions and isolated adrenocorticotropic (ACTH) deficiency without diabetes insipidus (DI). In addition, we review the literature summarizing the few reports of hypopituitarism in LCH in the absence of DI.Purpose With the improvement of techniques and the update of diagnostic protocols in breast cancer, modern imaging proves to be effective in the diagnosis of this pathology, as well as in its prognosis. This study aimed to evaluate the effectiveness of these modern imaging techniques through a systematic assessment of the most recent studies. Methods A PUBMED search, using certain key combinations ("breast cancer", "F18 FDG PET-CT", "MRI", "staging", "diagnosis") and some inclusion and exclusion criteria, yielded 24 articles published during 2014-2018. Results Using these 24 articles, the various statistical tests showed a significant difference between modern imaging techniques, with respect to prognosis (p less then 0.05), in close correlation with the immunohistochemical profile of the tumor. Conclusions Modern imaging techniques (F18-FDG/PET-CT, F18-FDG/PET-MRI) were validated to formulate a better prognostic value than conventional imaging, presenting a sustainable higher sensitivity and specificity in evidencing the locoregional invasion and the recurrence of this pathology.