These factors led to a more anti-inflammatory and pro-remodeling microenvironment within SimpliDerm, demonstrated by lower TNFα levels and lower expression levels of pro-fibrotic markers, and promoted tissue repair and regeneration by 3-months post-implantation.
 
  Overall, histology and gene expression profiling analyses shown in this study demonstrated an effective model for analyzing hADM performance in terms of host inflammatory and fibrotic response. Further studies are warranted to fully evaluate the utility of this novel hADM in the clinical setting and verify the prognosis of our pre-clinical analysis model.
 Overall, histology and gene expression profiling analyses shown in this study demonstrated an effective model for analyzing hADM performance in terms of host inflammatory and fibrotic response. Further studies are warranted to fully evaluate the utility of this novel hADM in the clinical setting and verify the prognosis of our pre-clinical analysis model.The aim of this study was to summarize the existing literature on the origin of the concept of the divine proportion and its usage in the plastic surgery field.
  In PubMed, the search terms [golden ratio AND (plastic surgery OR aesthetic surgery OR face)] were used, resulting in 65 articles. Among them, 15 articles were excluded and 50 abstracts were reviewed, of which 45 were excluded. The remaining 5 full articles and 11 other mined articles were reviewed.
 
  No evidence was found that the golden ratio had been used in any architecture or paintings before Pacioli's 
  (
  ) (1509), after which painters begin to use this ratio in their art. Fechner (1876) found that the golden ratio (11.618) was more aesthetically pleasing than any other proportion of rectangles. Recently Marquardt invented a facial mask containing decagons and pentagons that embody φ in all dimensions, and claimed that this mask yielded the most beautiful shape of the human face.  https://www.selleckchem.com/products/VX-770.html  However, it did not fit the average facial features of northwestern Europeans or their perceptions of ideal femininity.
 
  Mathematical regularity can be found in nature and in the human body. However, this does not necessarily mean that a "formula of beauty" exists in mathematics. From the contributions of modern aestheticians, we now know that the so-called "essence of beauty" cannot be derived from the mathematical "formula of beauty" in the object itself. Therefore, it is suggested that beauty is based on biology, rather than on mathematics.
 Mathematical regularity can be found in nature and in the human body. However, this does not necessarily mean that a "formula of beauty" exists in mathematics. From the contributions of modern aestheticians, we now know that the so-called "essence of beauty" cannot be derived from the mathematical "formula of beauty" in the object itself. Therefore, it is suggested that beauty is based on biology, rather than on mathematics.Burnout in medicine has become a national epidemic, affecting greater than one third of physicians, and yet physicians, departments, and institutions remain ill equipped to address it. Burnout is a syndrome characterized by emotional exhaustion, depersonalization, and a reduced sense of accomplishment that occurs as a response to one's environment. We have a moral and ethical imperative to address physician burnout, as it has immense implications within healthcare. Solutions have historically focused on changing the behavior of the individual, but research has demonstrated that long-lasting change is brought about by intervening at the organizational level, which requires that leadership champion these efforts. Departmental and hospital leadership play a critical role in addressing the drivers of burnout. Here, we outline evidence-based strategies to combat physician burnout at both the individual and organizational levels and review what has been explored within the field of plastic surgery.Vascularized omentum lymphatic transplant is frequently used for the treatment of lymphedema due to demonstrated efficacy, a reduced complication profile, and, in particular, negligible risk of donor site lymphedema. Historically harvested by open laparotomy, more recent techniques involve laparoscopic omental harvest. Although effective and reproducible, laparoscopy may be limited by reduced visualization, minimal tactile feedback, multiple port sites, and imprecise instrumentation. Therefore, we employed the da Vinci Single-Port (SP) surgical robot system for vascularized omentum lymphatic transplant. A 52-year-old man with a 3-year history of progressive left lower extremity swelling and lymphoscintigraphy and magnetic resonance lymphangiogram consistent with lymphedema of unknown etiology underwent vascularized omentum lymphatic transplant to the left groin. A 2.5-cm infraumbilical incision was used for placement of the primary trocar, through which the camera and operating instruments were passed. Following robotic harvest, the omental lymph node flap was transferred to the left groin for microsurgical anastomosis. The procedure was uneventful, and the patient was discharged on postoperative day 1. At 6 weeks, there were no complications. Here, we show for the first time the safety and feasibility of robotic omental lymph node flap harvest for extremity lymphedema using the da Vinci Single-Port robotic system. The benefits of this technology include a minimally-invasive approach that allows for flap dissection and removal through a single 2.5-cm incision. Further investigation is necessary to characterize the indications and limitations of this technique in plastic surgery.We report a case of E. coli osteomyelitis of the ribs in an immunocompetent 66-year-old man. After radical surgical debridement, bone and soft-tissue defects were covered with a rectus abdominis muscle flap. The postoperative course was uneventful, and there was no recurrence of chest symptoms. Among the various types of osteomyelitis, Gram-negative bacteria such as E. coli osteomyelitis is a relatively rare disease. Osteomyelitis is known to supervene in trauma or postoperative infection and to frequently begin with cellulitis, vascular access, endocarditis, or urinary tract infection, which spreads through the blood to the bone. To add to the difficulty of making a correct diagnosis, the early symptoms of osteomyelitis are often non-specific. We should never forget osteomyelitis in the differential diagnosis of these antecedent infections.