Metabolic glycan labeling (MGL) followed by bioorthogonal chemistry provides a powerful tool for tumor imaging and therapy. However, selectively metabolic labeling of cells or tissues of interest remains a challenge. Particularly, owing to tumor heterogeneity including tumor subtypes and interpatient heterogeneity, it is far more difficult to realize tumor-cell-selective metabolic labeling for precise diagnosis. Inspired by nature, we designed azidosugar-functionalized metal-organic frameworks camouflaged with cancer cell membranes to accomplish cancer-cell-selective MGL in vivo. With abundant receptors, this biomimetic platform not only selectively targets homotypic cells but also realizes different breast cancer subtype-selective MGL. Moreover, the endo/lysosomal-escaped ZIF-8 can make azidosugar escape from lysosomes and accelerate its metabolic incorporation. This strategy also takes advantage of cancer-tissue-derived cell membranes, which may have huge potential for personalized diagnosis and therapy.
  Deprescribing is the health-professional-supervised process of withdrawal of an inappropriate medication to manage polypharmacy and improve patient outcomes. Given the harms of polypharmacy and associated inappropriate medicines, practitioners, especially general practitioners (GPs), are encouraged to take a proactive role in deprescribing in older patients. While trial evidence for benefits of deprescribing is accumulating, there is currently little epidemiologic evidence of clinicians' (including GPs') deprescribing behaviours. We aimed to establish the prevalence and explore associations of deprescribing of inappropriate medicines by early-career GPs.
 
  A cross-sectional analysis of the ReCEnT study of GP registrars' in-consultation experience, 2016-18. Participants recorded 60 consecutive consultations, three times at 6-month intervals, including medicines ceased (our measure of deprescribing).  https://www.selleckchem.com/products/lificiguat-yc-1.html  The outcome was deprescribing of an inappropriate medicine (defined by a synthesis of three accepted classific03 per minute increase in duration).
 
  These findings will have important implications for the education of GPs in deprescribing as a clinical skill.
 These findings will have important implications for the education of GPs in deprescribing as a clinical skill.A metal-organic framework (MOF) having superprotonic conductivity, MOF-808, is prepared by modulating the binding mode of the sulfamate (SA) moieties grafted onto the metal clusters. The activation of the SA-grafted MOF-808 at 150 °C changes the binding mode of the grafted SA from monodentate to bridging bidentate, thus converting the neutral amido (-S-NH2 ) moiety of the grafted SA to the more acidic cationic sulfiliminium (-S=NH2 + ) moiety. Further, the acidic sulfiliminium moiety of MOF-808-4SA-150 results in more efficient proton conduction than the amido moiety of MOF-808-4SA-60. At 60 °C and 95 % relative humidity, MOF-808-4SA-150 is found to have a proton conductivity of 7.89×10-2  S cm-1 , which is more than 30-times higher than that of MOF-808-4SA-60. Moreover, this superprotonic conductivity is well maintained over 1000 cycles of conductivity measurements and for similar cyclic measurements each day for seven days.
  There are limited data in the literature about the short- to mid-term results of children with flexor tendon injuries. We aim to evaluate the short- to mid-term functional outcomes of children with flexor tendon injuries and to disclose whether the injured side affects the results.
 
  Patients who had undergone primary flexor tendon repair were included in the study. The demographic and clinical characteristics of the patients were recorded. Modified Hand Injury Severity Score was calculated for each patient. Sensory, motor and functional assessments of the bilateral hand were performed.
 
  A total of 44 patients (female = 16, male = 28) with a median age of 13 (6-17) were evaluated. Significant differences between the affected and healthy hands of the patients in terms of grip and pinch strengths and monofilament sensory test results were demonstrated while the Jebson Taylor Hand Function Test (JTHFT) scores were similar. No factor other than the injury side was found to be related to the affected hand functions. In patients with dominant hand injuries, JTHFT results of the affected hands were similar to the results of healthy dominant hands (P=.935). However, JTHFT results were found to be worse in the affected non-dominant hands compared to healthy non-dominant hands (P=.01).
 
  This study demonstrated that paediatric population with flexor tendon injuries in their dominant hands has better short- to mid-term functional outcomes. These results may be attributed to use their injured dominant hand more actively in daily activities.
 This study demonstrated that paediatric population with flexor tendon injuries in their dominant hands has better short- to mid-term functional outcomes. These results may be attributed to use their injured dominant hand more actively in daily activities.
  This study aimed to investigate the effects of diet and regular exercise on resilience in obese or overweight women.
 
  The study was conducted with the 109 patients who applied to the obesity polyclinics. The patients were divided into three groups by their current disease conditions and willingness; those who were willing to both diet and exercise (diet+exercise group) (n 35), those who were willing to only diet (diet group) (n 37) and those who were not willing to recommended diet or exercise (control group) (n 37). The "Connor-Davidson Resilience Scale" (CD-RISC) was applied to all the participants through face-to-face interviews. The CD-RISC scale was repeated 8weeks after the first evaluation.
 
  There was a significant difference between the total score and subscores of the scale in the intra-group comparison before and after the intervention (P<.05). When the groups were compared after the intervention, a significant difference was found between the diet group and the control group as well as the exercise +diet group and the control group (P<.05).
 
  We found that diet and exercise practices increased psychological endurance in obese or overweight women. In addition, positive improvements were also detected in psychological resilience subgroups such as perseverance and personal competence, tolerance to negative events and spiritual disposition.
 We found that diet and exercise practices increased psychological endurance in obese or overweight women. In addition, positive improvements were also detected in psychological resilience subgroups such as perseverance and personal competence, tolerance to negative events and spiritual disposition.