4 (95% CI 5.2-7.6) for new users; the corresponding SIRs were 3.1 (95% CI 2.9-3.3) and 3.5 (95% CI 2.9-4.3). In the second and subsequent years, the SIRs diminished and approached unity for both prevalent (1.1 [95% CI 1.1-1.2]) and new users (1.1 [95% CI 0.9-1.3]). VTE patients using statins had a 3-fold increased rate of cancer in the first year after diagnosis. A first VTE serves as an important marker of cancer, regardless of statin use. VTE patients using statins had a 3-fold increased rate of cancer in the first year after diagnosis. A first VTE serves as an important marker of cancer, regardless of statin use. Açai is a rich source of anthocyanins and has been used as a dietary supplement and as an active pharmaceutical ingredient. Growing evidence indicates that host-microbial interactions played a vital role in the host metabolism. The aim of this study was to investigate the anthocyanin-rich extract of açai (Euterpe oleracea Mart.) fruit (AEA) regarding its antiobesity activity and gut microbiota-modulating effect. Thirty-six male SPF C57BL/6J mice were randomly divided into three groups and fed a low-fat diet, high-fat diet, or a high-fat diet supplemented with AEA for 14 wk. The antiobesity effect of AEA was evaluated, and the microbial changes were analyzed by 16S rRNA sequencing. Spearman correlation analysis was used to determine the correlations between gut microbiota and obesity-related indicators. The results showed that AEA treatment alleviated HFD-induced obesity, hepatic steatosis, and insulin resistance. Moreover, AEA supplement changed the structure of the gut microbiota, and significantly enriched Akkermansia muciniphila, which was negatively correlated with the physical biomarkers (e.g., serum glucose, insulin, and triacylglycerols) and the genes involved in lipid metabolism. AEA alleviated high-fat diet-induced obesity, insulin resistance, and hepatic steatosis. The microbial changes may be one of the potential mechanisms for AEA in improving obesity and obesity-related disorders. AEA alleviated high-fat diet-induced obesity, insulin resistance, and hepatic steatosis. The microbial changes may be one of the potential mechanisms for AEA in improving obesity and obesity-related disorders. This study evaluated the adequacy of micronutrient intake from the ketogenic diet (KD) with and without micronutrient supplementation according to age in Brazilian children and adolescents with refractory epilepsy undergoing KD treatment. This study enrolled children and adolescents with refractory epilepsy who were up to 19 y of age. Nutrient intakes were monitored using 3 d food records before introducing micronutrient supplementation and 3 mo after starting KD treatment. The prevalence of micronutrient inadequacy was estimated by sex and age according to the estimated average requirement cutoff values. This study included 39 children and adolescents. The KD did not provide enough content of folate, calcium, and magnesium in all patients according to the dietary reference intake. Even after starting supplementation, calcium, phosphorus, and magnesium intake remained inadequate in the majority of patients. The supplementation effectively met the vitamin B recommendation in all age groups. KD treatment did not provide adequate levels of the monitored micronutrients. The supplementation improved but did not prevent the inadequacy of micronutrients such as calcium, magnesium, and phosphorus. The results highlight the importance of individual supplementation protocols and the need to monitor micronutrient intake according to age and sex. KD treatment did not provide adequate levels of the monitored micronutrients. The supplementation improved but did not prevent the inadequacy of micronutrients such as calcium, magnesium, and phosphorus. The results highlight the importance of individual supplementation protocols and the need to monitor micronutrient intake according to age and sex. To compare radiation dose, contrast enhancement, image noise and heart rate variability in electrocardiography (ECG)-gated computed tomography (CT) ventricular volumetry using a three-dimensional (3D) threshold-based segmentation between the conventional single scan and dual focused scan methods in patients with congenital heart disease. After matching for age, sex, heart rate during the CT examination, and tube voltage, 96 patients (age range, 7 - 36 years; malefemale = 6333) who underwent ECG-gated CT volumetry using a 3D threshold-based segmentation, were divided into 32 patients who underwent a conventional single scan (group 1) and 64 who underwent dual focused scans (group 2). CT radiation dose, contrast enhancement, image noise, and heart rate variability were compared between the two groups. Volume CT dose index, dose-length product, and effective dose estimates, in group 1 were significantly higher than those in group 2 (28.4 ± 24.6 mGy vs. 9.7 ± 4.5 mGy, 636.5 ± 572.9 mGy cm vs. 379.5 ± 192.4  lower radiation dose with comparable contrast enhancement and image noise for ECG-gated CT ventricular volumetry using a 3D threshold-based segmentation in patients with congenital heart disease. This article reviews the pathological mechanisms and progress of imaging of severe frostbite to assist in the search for targets for clinical diagnosis and treatment of severe frostbite. This review also aims to provide strong evidence for clinical diagnosis and treatment of deep frostbite. The review was based on the summary and analysis of the existing literature, and explored the pathological mechanism of deep frostbite and the advantages and disadvantages of imaging diagnostic methods. According to the depth of tissue involvement, frostbite is divided into 4 levels. Severe frostbite includes Grade 3 and Grade 4 frostbite. Clinical performance evaluation and imaging diagnostic research have always been the mainstream of severe frostbite diagnosis. Imaging methods focus on vascular patency and tissue vitality. https://www.selleckchem.com/products/ak-7.html This article introduces angiography, SETCT/CT and MRA, and we summarize the advantages and disadvantages of these imaging methods. We recommend corresponding imaging modalities according to the state of frostbite patients.