https://www.selleckchem.com/products/hs94.html Biochemical measures of total RAB39B levels within the temporal cortex were unchanged between DLB, AD and controls. However, upon subcellular fractionation, a reduction of RAB39B in the cytoplasmic pool was found in DLB cases, alongside an increase of phosphorylated aSyn and Aβ in whole tissue lysates. The reduction of cytoplasmic RAB39B is consistent with an impaired reserve capacity for RAB39B-associated functions, which in turn may facilitate LB aggregation and synaptic impairment. Collectively, our data support the involvement of RAB39B in the pathogenesis of DLB and the co-aggregation of RAB39B with Aβ in plaques suggests that age-associated cerebral Aβ pathology may be contributory to the loss of RAB39B. Thus RAB39B, its associated functional pathways and its entrapment in aggregates may be considered as future targets for therapeutic interventions to impede the overall pathological burden and cellular dysfunction in Lewy body diseases.A current global concern is the millions of refugees fleeing their homeland due to political and socio-economic challenges and seeking assistance worldwide. An effective response to the refugee crisis includes support models that meet the various needs of refugee populations. In the complex system of humanitarian action, among a multiplicity of actors, humanitarian aid workers are the most important assets. Using the inclusion-exclusion theoretical lens, we examined the impact of their workplace experiences on aid activities in the context of the refugee crisis in Lebanon. We conducted in-depth interviews with thirty-six humanitarian practitioners, working in five international organizations that are involved in refugee aid programs in the country. Our study develops a new understanding of the link between inclusion-exclusion and the effectiveness of the humanitarian response to crises. It also brings new insights into the apprehension of the national-international divide and its im