https://www.selleckchem.com/products/eliglustat.html ous system alterations related to central neuropathic pain in MS patients that lead to the disturbances in cortical communication. Copyright © 2020 Krupina, Churyukanov, Kukushkin and Yakhno.Glucocorticoids are used intra-operatively in cochlear implant surgeries to reduce the inflammatory reaction caused by insertion trauma and the foreign body response against the electrode carrier after cochlear implantation. To prevent higher systemic concentrations of glucocorticoids that might cause undesirable systemic side effects, the drug should be applied locally. Since rapid clearance of glucocorticoids occurs in the inner ear fluid spaces, sustained application is supposedly more effective in suppressing foreign body and tissue reactions and in preserving neuronal structures. Embedding of the glucocorticoid dexamethasone into the cochlear implant electrode carrier and its continuous release may solve this problem. The aim of the present study was to examine how dexamethasone concentrations in the electrode carrier influence drug levels in the perilymph at different time points. Silicone rods were implanted through a cochleostomy into the basal turn of the scala tympani of guinea pigs. The silicone roilicone electrode carrier dummies in a controlled and sustained way over a period of several weeks, leading to constant drug concentrations in the scala tympani perilymph. No accumulation of dexamethasone was observed in the cochlear tissue. In consideration of experimental studies using similar drug depots and investigating physiological effects, an effective dose range between 50 and 100 ng/ml after burst release is suggested for the CI insertion trauma model. Copyright © 2020 Liebau, Schilp, Mugridge, Schön, Kather, Kammerer, Tillein, Braun and Plontke.[This corrects the article DOI 10.3389/fneur.2018.00395.]. Copyright © 2020 Teggi, Colombo, Albera, Asprella Libonati, Balzanelli, Batuecas Caletrio, Casani, Espinosa-San