https://www.selleckchem.com/products/kc7f2.html 001). Regarding the specific detection of the allele, the PCR protocol had a sensitivity of 100% (95% CI 91.61-100%) and specificity of 98.3% (95% CI 90.9-99.7%). The protocol was used to determine the distribution of the allele in 810 unrelated Vietnamese Kinh people, 14.2% of which were carriers, the allele frequency was 7.5%. A novel AS-PCR protocol with a sensitivity of 100% for the detection of the allele was established. The protocol can be used for personalized treatment with allopurinol in order to minimize the risk of SCARs in Vietnamese people as well as in other Asian populations with similar genetic characteristics. A novel AS-PCR protocol with a sensitivity of 100% for the detection of the HLA-C*0302 allele was established. The protocol can be used for personalized treatment with allopurinol in order to minimize the risk of SCARs in Vietnamese people as well as in other Asian populations with similar genetic characteristics. A number of childhood diseases have been identified, such as severe infection or autoinflammatory disease, in which immune overreaction against inflammation is a possible underlying mechanism. Previous reports have demonstrated that fetal cells exposed to maternal immune activation (MIA) induced by polyriboinosinic-polyribocytidylic acid [poly(IC)] exhibited hypersensitivity to inflammation in vitro. However, the details of this mechanism remain unclear. Therefore, this study aimed to reveal the reaction to inflammation in offspring exposed to MIA in the prenatal period, as well as its molecular mechanism, using a viral infection mouse model. Pregnant mice at 12.5, 14.5, and 16.5 days post coitum were injected intraperitoneally with poly(IC) 20 mg/kg body weight (BW) or saline. Offspring aged 3-4 weeks received the second injection of 20 mg/kg BW or 4 mg/kg BW poly(IC) or saline. Serum and tissues were collected at 2, 24, 48, and 72 h after the postnatal injection. The cytokine profile