https://www.selleckchem.com/products/iwp-2.html is will in effect reduce the time spent by radiology staff in educating and gaining patients' compliance during such examinations resulting in a decrease in waiting and scanning time leading to an overall increase in workflow. Ground-glass nodules may be the expression of benign conditions, pre-invasive lesions or malignancies. The aim of our study was to evaluate the capability of chest digital tomosynthesis (DTS) in detecting pulmonary ground-glass opacities (GGOs). An anthropomorphic chest phantom and synthetic nodules were used to simulate pulmonary ground-glass nodules. The nodules were positioned in 3 different regions (apex, hilum and basal); then the phantom was scanned by multi-detector CT (MDCT) and DTS. For each set (nodule-free phantom, nodule in apical zone, nodule in hilar zone, nodule in basal zone) seven different scans (n=28) were performed varying the following technical parameters Cu-filter (0.1-0.3mm), dose rateo (10-25) and X-ray tube voltage (105-125kVp). Two radiologists in consensus evaluated the DTS images and provided in agreement a visual score 1 for unidentifiable nodules, 2 for poorly identifiable nodules, 3 for nodules identifiable with fair certainty, 4 for nodules identifiable with absolute certainty. Increasing the dose rateo from 10 to 15, GGOs located in the apex and in the basal zone were better identified (from a score=2 to a score=3). GGOs located in the hilar zone were not visible even with a higher dose rate. Intermediate density GGOs had a good visibility score (score=3) and it did not improve by varying technical parameters. A progressive increase of voltage (from 105kVp to 125kVp) did not provide a better nodule visibility. DTS with optimized technical parameters can identify GGOs, in particular those with a diameter greater than 10mm. DTS could have a role in the follow-up of patients with known GGOs identified in lung apex or base region. DTS could have a role in the follow-