https://www.selleckchem.com/products/urmc-099.html The switch/sucrose-nonfermenting (SWI/SNF) nucleosome complex consists of several proteins that are involved in cellular proliferation and tumor suppression. The aim of this study was to correlate immunohistochemical expression of four SWI/SNF complex subunits, SMARCA2, SMARCB1, SMARCA4, and ARID1A, with clinicopathologic and molecular features and patient survival in 338 patients with colorectal adenocarcinoma using a tissue microarray approach. Twenty-three (7%) colorectal adenocarcinomas demonstrated deficient SWI/SNF expression 7 had SMARCA2 deficiency, 12 had ARID1A deficiency, and 4 had both SMARCA2 and ARID1A deficiency. No cases were SMARCB1 or SMARCA4-deficient. Twelve (52%) SWI/SNF complex-deficient tumors demonstrated MMR deficiency (p=0.02), 6 (26%) showed medullary differentiation (p=0.001), and 9 were negative for CDX2 expression (p0.05). In conclusion, SMARCA2-deficient and ARID1A-deficient colorectal carcinomas had distinctly different clinicopathologic features with ARID1A-deficient tumors exhibiting medullary and mucinous differentiation and MMR deficiency, and SMARCA2-deficient tumors demonstrating conventional gland-forming histologic growth with less frequent MMR deficiency. Cases of new pseudotumor of the liver were collected from multiple medical centers. Four resection and 4 biopsy specimens were collected, including 4 women and 4 men with an average age of 48+15 years, range 28 to 73. The lesions were visible on imaging, but were either ill-defined or had indeterminate features for characterization. They ranged in size from 2 to 9 cm and were multiple in five cases. The resection specimens showed lesions that had vague borders but were visible in juxtaposition to the normal liver on gross examination. Histologically, the lesions also had ill-defined borders and were composed of benign reactive liver parenchyma. Central vein thrombi were seen in 5 cases and portal vein thrombi in 2 cases. The